Table 1.
Baseline characteristics by t(11;14) status.
| Characteristic – median range or no. (%) | t(11;14): absent (n = 292) | t(11;14) present (n = 102) | P Value |
|---|---|---|---|
| Median age (range) | 61.2 (23.5–76.9) | 63.2 (38.4–78.3) | 0.29a |
| Sex (n = 394), Male | 159 (54.5) | 65 (63.7) | 0.10b |
| Race | 0.24b | ||
| White | 245 (83.9) | 91 (89.2) | – |
| Black or African American | 35 (12.0) | 7 (6.9) | – |
| Other | 8 (2.7) | 1 (1.0) | – |
| Unknown | 4 (1.4) | 3 (2.9) | – |
| Karnofsky score ≥90 (n = 287) | 134 (45.9) | 46 (45.1) | 0.76b |
| HCT-CI | 0.32b | ||
| 0 | 52 (17.8) | 22 (21.6) | – |
| 1 | 36 (12.3) | 11 (10.8) | – |
| 2 | 49 (16.8) | 10 (9.8) | – |
| 3+ | 155 (53.1) | 59 (57.8) | – |
| Cardiac involvement (n = 336) | 141 (48.3) | 65 (63.7) | 0.02b |
| Renal involvement (n = 314) | 212 (72.6) | 69 (67.6) | 0.03b |
| Liver involvement (n = 364) | 34 (11.6) | 14 (13.7) | 0.67b |
| Organ involvement | <.01b | ||
| 1 | 127 (43.5) | 26 (25.5) | – |
| 2 | 90 (30.8) | 45 (44.1) | – |
| ≥3 | 75 (25.7) | 31 (30.4) | – |
| Serum creatinine at diagnosis <2 mg/dl (n = 365) | 226 (77.4) | 92 (90.2) | 0.01b |
| Serum albumin at diagnosis <3.5 g/dL (n = 352) | 172 (58.9) | 57 (55.9) | – |
| Bone marrow plasma cells at diagnosis | 0.07b | ||
| <10% | 178 (61.0) | 60 (58.8) | – |
| ≥10% | 88 (30.1) | 39 (38.2) | – |
| Missing | 26 (8.9) | 3 (2.9) | – |
| Time from diagnosis to transplant - median (min-max) | 5.4 (1.0–9.0) | 5.7 (1.5–8.8) | 0.90a |
| Bortezomib used in induction | 203 (69.5) | 67 (65.7) | 0.47b |
| Melphalan dose in conditioning regimen, mg/m | <.01b | ||
| MEL100 | 34 (11.6) | 11 (10.8) | – |
| MEL140 | 100 (34.2) | 16 (15.7) | – |
| MEL180 | 45 (15.4) | 11 (10.8) | – |
| MEL200 | 113 (38.7) | 64 (62.7) | – |
| Year of transplant | 0.06b | ||
| 2014 | 57 (19.5) | 18 (17.6) | – |
| 2015 | 61 (20.9) | 25 (24.5) | – |
| 2016 | 69 (23.6) | 24 (23.5) | – |
| 2017 | 71 (24.3) | 14 (13.7) | – |
| 2018 | 34 (11.6) | 21 (20.6) | 2018 |
| Follow-up - median (range) | 24.8 (3.3–62.8) | 25.2 (3.5–59.8) | – |
Hypothesis testing:
aKruskal–Wallis test.
bPearson χ2 test.