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. 2023 Nov 15;14:7385. doi: 10.1038/s41467-023-43315-x

Fig. 1. Increased PUFA biosynthesis in BCG-trained monocytes is associated with eicosanoid and docosanoid biosynthesis after 24 hours.

Fig. 1

Levels of PUFA and oxylipids in stimulated monocytes at 24 h with BG, BCG, and LPS (n = 4-8 biologic replicates, pooled from 4 independent experiments), a Arachidonic acid pathway (AA), b Eicosapentaenoic acid (EPA), and c Docosahexaenoic acid (DHA) pathway. Violin plots showing median and the interquartile region, Friedman’s test followed by Dunn’s multiple comparisons test. Area ratios (A.R), corrected for internal standards and protein content are shown. (Ctrl control, BG β-glucan, BCG Bacillus Calmette-Guérin, LPS lipopolysaccharide, LOX lipoxygenase, COX cyclooxygenase, PG prostaglandin, Tx thromboxane, LT leukotriene, HETE hydroxyeicosatetraenoic acid, HEPE hydroxyeicosapentaenoic acid, HDHA hydroxy docosahexaenoic acid).