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. 2023 Nov 15;13:19960. doi: 10.1038/s41598-023-46253-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Real and pix2pix GAN based synthesized OCT B-scans of two patients (rows) showing baseline (left), real M12 (center) and synthetic M12 (right) B-scans. The RNFL thinning in a slow progressing case (top row) and a fast progressing case (bottom row) is demarcated by orange and red coloured outlines respectively. The thinning of RNFL as shown from the baseline to M12 images is also captured well by the synthetic M12 images.