TABLE 2.

MRS data analysis of GABA and Glx levels.

	GABA IU (SNR)		Glx IU (SNR)		GABA/Glx
	Pre‐treatment	Post‐treatment	Pre‐treatment	Post‐treatment	Pre‐treatment	Post‐treatment
etFUS
Subject 1	2.440 (11.60)	2.496 (10.35)	5.229 (11.74)	6.849 (11.39)	0.467	0.364
Subject 2	3.272 (12.23)	2.778 (14.76)	7.203 (10.08)	6.820 (11.62)	0.454	0.407
Subject 3	2.702 (12.91)	2.210 (15.45)	6.168 (12.54)	7.279 (13.48)	0.438	0.304
Subject 4	2.725 (14.75)	2.881 (10.13)	6.780 (10.11)	7.181 (12.31)	0.402	0.401
Mean ± SEM	2.785 ± 0.175	2.591 ± 0.151	6.345 ± 0.428	7.032 ± 0.116	0.440 ± 0.014	0.369 ± 0.024 (p = 0.095)
itFUS
Subject 5	2.911 (12.32)	4.931 (11.60)	7.578 (12.08)	8.457 (9.92)	0.384	0.583
Subject 6	2.084 (13.70)	2.266 (11.94)	6.313 (13.92)	6.190 (11.94)	0.330	0.366
Subject 7	2.135 (12.83)	2.395 (10.19)	5.103 (12.62)	5.135 (11.90)	0.419	0.466
Subject 8	2.622 (10.92)	3.216 (12.40)	6.818 (10.28)	6.633 (11.10)	0.385	0.485
Subject 9	2.907 (9.85)	2.502 (12.20)	6.658 (8.70)	5.169 (10.20)	0.437	0.384
Mean ± SEM	2.532 ± 0.180	3.062 ± 0.495	6.494 ± 0.405	6.317 ± 0.609	0.391 ± 0.018	0.477 ± 0.034*

Note: Significant differences of GABA/Glx between pre‐treatment and post‐treatment are tested by paired t test with p < 0.05 accepted as significant.

Abbreviation: SNR, Signal‐to‐Noise Ratio.

^*Asterisk significant differences between before and after consecutive tFUS stimulation (*p < 0.05).