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. 2023 Nov 15;14:7384. doi: 10.1038/s41467-023-42390-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Representative microscopy images of immunofluorescence (IF) assay in MRC5 cells showing, after 16 J/m² UV-C irradiation, the localization of SMN (red) and (a) RNAP1, (b) FBL or (c) Coilin (green) at different times Post UV-Irradiation (PUVI). Nuclei and nucleoli are indicated by dashed and dotted lines respectively. Scale bar: 5 µm. d–g Quantification of cells number for localization of (d) SMN, (g) Coilin (in Cajal Bodies [CBs] or Gems, at the periphery of the nucleolus or mixed localization), (e) RNAP1 and (f) FBL (inside the nucleolus, outside the nucleolus or mixed localization) at different times PUVI. For Coilin, RNAP1 and FBL, at least 50 cells from one representative experiment were analyzed. The SMN graph represent the average of three independent experiments, of which at least 50 cells for each were analyzed. Source data of graphs are provided as a Source Data file.