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. 2023 Nov 15;14:7384. doi: 10.1038/s41467-023-42390-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Representative microscopy images of immunofluorescence (IF) assay showing the localization of SMN (red) and FBL (green) at different times Post UV-Irradiation (PUVI) in cells transfected with siMock or siPRMT1 pool. Nuclei and nucleoli are indicated by dashed and dotted lines respectively. Scale bar: 5 µm. b, c Quantification of cells number for localization of (b) SMN (in Cajal Bodies [CBs] or Gems, at the periphery of the nucleolus or mixed localization) and (c) FBL (inside the nucleolus, outside the nucleolus or mixed localization) at different times PUVI in cells transfected with siMock or siPRMT1 pool. At least 145 cells from one representative experiment were analyzed. d Representative microscopy images of IF assay showing the localization of SMN (red) and FBL (green) in MRC5 cells treated with DMSO, MS023 or Furamidine followed by 16 J/m² UV-C irradiation. Nuclei and nucleoli are indicated by dashed and dotted lines respectively. Scale bar: 5 µm. e Quantification of cells number for localization of SMN (in Cajal Bodies [CBs] or Gems, at the periphery of the nucleolus or mixed localization) at different times PUVI in cells treated with DMSO, MS023 or Furamidine. At least 60 cells from one representative experiment were analyzed. Source data of graphs are provided as a Source Data file.