Table 1.
Baseline demographics of trials and populations included in meta-analysis. Values are percentages unless stated otherwise
| Trial, year | No of patients | Median age, years | Men | Smoking | HTN | HLD | Diabetes | Previous MI | Previous PCI | Previous CABG | LVEF | Stable angina | ACS | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IVUS versus coronary angiography guided PCI | ||||||||||||||||||
| HOME DES IVUS, 200912 | 105/105 | 59/60 | 73/71 | 40/35 | 67/71 | 63/66 | 42/45 | 37/32 | 17/14 | 14/10 | NR | 38/40 | 62/60 | |||||
| RESET, 201313 | 269/274 | 63/64 | 66/55 | 22/17 | 61/66 | 61/62 | 32/30 | 1/3 | - | - | 55/54 | 53/52 | 47/48 | |||||
| AVIO, 201314 | 142/142 | 64/64 | 82/77 | 35/31 | 70/67 | 70/77 | 24/27 | - | - | - | 55/56 | 70/64 | 30/26 | |||||
| Wang et al, 201415 | 38/42 | 56/54 | 60/67 | 50/59 | 39/24 | 26/24 | 21/12 | - | - | - | 50/48 | 0/0 | 100/100 | |||||
| MOZART, 201416 | 41/42 | 67/62 | 61/57 | 42/40 | 98/100 | - | 73/81 | - | 274/12 | 15/17 | NR | 76/71 | 15/17 | |||||
| AIR CTO, 201517 | 115/115 | 67/66 | 89/80 | 39/39 | 75/70 | 22/28 | 30/27 | 21/30 | - | - | 55/56 | 71/76 | 29/24 | |||||
| CTO-IVUS, 201518 | 201/201 | 61/61 | 81/81 | 35/34 | 63/64 | - | 35/34 | 8/8 | 15/16 | 2/3 | 57/57 | 100/100 | 0/0 | |||||
| IVUS-XPL, 20202 | 700/700 | 64/64 | 69/69 | 22/26 | 65/63 | 67/65 | 36/37 | 5/4 | 11/10 | 3/2 | 63/62 | 51/51 | 49/49 | |||||
| Tan et al, 201519 | 61/62 | 77/76 | 62/69 | 44/47 | 41/47 | - | 34/30 | 16/21 | - | - | 55/53 | 30/34 | 70/66 | |||||
| Liu et al, 201920 | 167/169 | 65/65 | 64/64 | 37/36 | 70/72 | 38/38 | 34/31 | 17/14 | 20/17 | 1/1 | 56/58 | 12/11 | 86/87 | |||||
| ULTIMATE, 202121 | 724/724 | 65/66 | 74/73 | 35/32 | 71/72 | 54/55 | 30/31 | 9/12 | 17/20 | 1/1 | 61/60 | 13/13 | 79/78 | |||||
| OCT versus coronary angiography guided PCI | ||||||||||||||||||
| OCTACS, 201522 | 50/50 | 62/63 | 72/68 | 46/36 | 56/56 | 44/38 | 16/10 | 4/0 | 6/4 | 0/0 | - | 0/0 | 100/100 | |||||
| DOCTORS, 201623 | 120/120 | 61/60 | 79/76 | 42/41 | 42/49 | 47/48 | 16/19 | - | - | - | - | 0/0 | 100/100 | |||||
| ROBUST, 201824 | 105/96 | 57/59 | 83/87 | 64/59 | 50/52 | - | 17/26 | 1/6 | 4/4 | 0/0 | - | 0/0 | 100/100 | |||||
| OPTIMUM, 202025 | 56/54 | 69/69 | 79/74 | 23/18 | 77/74 | 86/85 | 52/46 | 16/15 | 4/0 | 21/35 | 61/60 | 91/91 | 9/9 | |||||
| ILUMIEN IV: OPTIMIZE PCI 20234 | 1233/1254 | 65/66 | 78/76 | 19/20 | 71/74 | 66/69 | 42/42 | 20/24 | 13/13 | 63/53 | 55/55 | 27/29 | 63/61 | |||||
| OCTOBER, 20233 | 600/601 | 66/66 | 69/69 | 50/51 | 70/75 | 76/78 | 17/16 | 28/30 | 41/43 | 1/2 | 59/58 | 55/53 | 45/47 | |||||
| IVUS/OCT versus coronary angiography guided PCI | ||||||||||||||||||
| iSIGHT, 202126 | 50/51/49 | 59/60/59 | 36/31/38 | 14/17/14 | 42/46/39 | 30/36/28 | - | - | - | - | - | 35/34/35 | 36/33/36 | |||||
| ILUMIEN III: OPTIMIZE PCI, 202127 | 136/153/142 | 66/66/67 | 74/69/73 | 13/17/23 | 78/78/75 | 75/73/77 | 36/33/28 | - | - | - | - | 35/34/35 | 36/33/36 | |||||
| RENOVATE-COMPLEX-PCI, 202328 | 1092/547 | 65/66 | 79/79 | 19/17 | 62/59 | 51/51 | 36/41 | 7/8 | 24/23 | - | 58/59 | 49/50 | 51/50 | |||||
ACS=acute coronary syndrome; AVIO=Angiography Versus IVUS Optimization; CABG=coronary artery bypass graft; CTO IVUS=Chronic Total Occlusion InterVention with drUg-eluting Stents guided by IVUS; DOCTORS=Does Optical Coherence Tomography Optimize Results of Stenting; HLD=hyperlipidemia; HTN=hypertension; ILUMIEN IV=Optical Coherence Tomography (OCT) Guided Coronary Stent Implantation Compared with Angiography: A Multicenter Randomized Trial in PCI; iSIGHT=Optical Coherence Tomography Versus Intravascular Ultrasound and Angiography to Guide Percutaneous Coronary Interventions; IVUS=intravascular ultrasonography; IVUS-XPL=Impact of Intravascular Ultrasound Guidance on the Outcomes of Xience Prime Stents in Long Lesions; LVEF=left ventricular ejection fraction; MI=myocardial infarction; MOZART=Minimizing cOntrast utiliZation With IVUS Guidance in coRonary angioplasty; OCT=optical coherence tomography; OCTACS=Optical Coherence Tomography Guided Percutaneous Coronary Intervention With Nobori Stent Implantation in Patients With Non-ST-Segment-Elevation Myocardial Infarction; OCTOBER=OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions; OPTIMUM=Online 3-Dimensional Optical Frequency Domain Imaging to Optimize Bifurcation Stenting Using UltiMaster Stent; PCI=percutaneous coronary intervention; RENOVATE COMPLEX-PCI=Randomized Controlled Trial of Intravascular Imaging Guidance versus Angiography-Guidance on Clinical Outcomes after Complex Percutaneous Coronary Intervention; RESET=Real Safety and Efficacy of a 3-Month Dual Antiplatelet Therapy Following Zotarolimus-Eluting Stents Implantation; ULTIMATE=Intravascular Ultrasound Guided Drug Eluting Stents Implantation in “All-Comers” Coronary Lesions.