Table 2.
Anticipated absolute risk differences (ARD) per 1000 people with 95% confidence intervals (CI) of intravascular imaging on outcomes in patients undergoing percutaneous coronary intervention (PCI) across different coronary artery disease risk categories at five years
| Risk categories | Rate ratio (95% CI) | Baseline risk for coronary angiography guided PCI | ARD (95% CI) with intravascular imaging guided PCI per 1000 people | Certainty of evidence (GRADE) |
|---|---|---|---|---|
| Low risk (SYNTAX: 0-22) | ||||
| Cardiac death | 0.53 (0.39 to 0.72) | 48 per 1000 | 23 (29 to 13) fewer | High |
| Myocardial infarction | 0.81 (0.68 to 0.97) | 78 per 1000 | 15 (25 to 2) fewer | High |
| Stent thrombosis | 0.44 (0.27 to 0.72) | 16 per 1000 | 9 (12 to 4) fewer | High |
| Target vessel revascularization | 0.74 (0.61 to 0.89) | 108 per 1000 | 28 (42 to 12) fewer | High |
| Target lesion revascularization | 0.71 (0.59 to 0.86) | 121 per 1000 | 35 (50 to 17) fewer | High |
| All cause death | 0.81 (0.64 to 1.02) | 89 per 1000 | 17 fewer (32 fewer to 2 more) | Moderate |
| Intermediate risk (SYNTAX: 22-32) | ||||
| Cardiac death | 0.53 (0.39 to 0.72) | 88 per 1000 | 41 (54 to 25) fewer | High |
| Myocardial infarction | 0.81 (0.68 to 0.97) | 112 per 1000 | 21 (36 to 3) fewer | High |
| Stent thrombosis | 0.44 (0.27 to 0.72) | 19 per 1000 | 11 (14 to 5) fewer | High |
| Target vessel revascularization | 0.74 (0.61 to 0.89) | 113 per 1000 | 29 (44 to 12) fewer | High |
| Target lesion revascularization | 0.71 (0.59 to 0.86) | 128 per 1000 | 37 (52 to 18) fewer | High |
| All cause death | 0.81 (0.64 to 1.02) | 138 per 1000 | 26 fewer (50 fewer to 3 more) | Moderate |
| High risk (SYNTAX ≥33) | ||||
| Cardiac death | 0.53 (0.39 to 0.72) | 136 per 1000 | 64 (83 to 38) fewer | High |
| Myocardial infarction | 0.81 (0.68 to 0.97) | 101 per 1000 | 19 (32 to 3) fewer | High |
| Stent thrombosis | 0.44 (0.27 to 0.72) | 23 per 1000 | 13 (17 to 6) fewer | High |
| Target vessel revascularization | 0.74 (0.61 to 0.89) | 145 per 1000 | 38 (57 to 16) fewer | High |
| Target lesion revascularization | 0.71 (0.59 to 0.86) | 164 per 1000 | 48 (67 to 23) fewer | High |
| All cause death | 0.81 (0.64 to 1.02) | 192 per 1000 | 36 fewer (69 fewer to 4 more) | Moderate |
GRADE=grading of recommendations, assessment, development, and evaluation; SYNTAX=synergy between percutaneous coronary intervention with taxus and cardiac surgery.