Table 1.
Gene Ontology concepts and KEGG pathways that are important for understanding ATH and risk factors such as SM, OB, DB, SLS, HF, AL, ST, HLP, ADT, HPT, HC, ATH.
| Biological Process (BP) | |||
|---|---|---|---|
| GO ID | Term/pathway | Genes | Risk factors |
| GO:0032387 | negative regulation of intracellular transport | CD84, PLN, LGALS9, CD300A | AL, HLP, SM, ST |
| GO:0043301 | negative regulation of leukocyte degranulation | CD84, CCR2, LGALS9, CD300A | AL, HF, OB, SM, ST |
| GO:0001819 | positive regulation of cytokine production | PDE4D, TNF, HAVCR2, CYBA, HILPDA, IRF5, CD14 | AL, HPT, OB, ST |
| GO:0032757 | positive regulation of interleukin-8 production | CD14, IL1B, TLR1, LGALS9, TNF, IL17D | DB, HPT, SLS, SM |
| GO:2000484 | positive regulation of interleukin-8 secretion | CD14, TLR1, LGALS9 | DB, SLS, SM, ST |
| Cellular Component (CC) | |||
|---|---|---|---|
| GO ID | Term/pathway | Genes | Risk factors |
| GO:0045334 | clathrin-coated endocytic vesicle | APOE, HLA-DQB2, HLA-DRB4, HLA-DQA1 | AL, HC, OB |
| GO:0030669 | clathrin-coated endocytic vesicle membrane | APOE, HLA-DQB2, HLA-DRB4, HLA-DQA1 | AL, HC, OB |
| GO:0005887 | integral component of plasma membrane | CD84, PLXND1, SORBS1, TRPM2, SLC6A6, CD6, SLCO2B1, SLMAP, STAB1, CD37, LGR6, STRA6, TSPAN10, CD33, CCR2, MSR1, CD52, IGSF6, FCER1G, TSPAN8, SCARA5, SLC40A1, CD36 | AL, HF, ST |
| GO:0071556 | integral component of luminal side of endoplasmic reticulum membrane | HLA-DRB4, HLA-DQA1, HLA-DRA | HC, OB, SM |
| GO:0005764 | lysosome | FUCA1, LIPA, DPP4, GM2A, HLA-DQA1, HLA-DRA, DCN, LGMN | DB, OB, SM |
| Molecular Function (MF) | |||
|---|---|---|---|
| GO ID | Term/pathway | Genes | Risk factors |
| GO:0019956 | chemokine binding | CX3CR1, CCR1, ITGA4 | HF, HPT, SLS |
| GO:0004950 | chemokine receptor activity | CX3CR1, CCR1, CCR2 | HF, HPT, OB |
| GO:0032395 | MHC class II receptor activity | HLA-DQB2, HLA-DQA1, HLA-DRA | AL, OB, SM |
| GO:0004435 | phosphatidylinositol phospholipase C activity | PLCB2, CCL5, CCR1 | ADT, HF, HPT |
| GO:0004629 | phospholipase C activity | PLCB2, CCL5, CCR1 | ADT, HF, HPT |
| KEGG pathways | |||
|---|---|---|---|
| KEGG ID | Pathway | Gene in pathway | Risk factors |
| hsa04062 | chemokine signaling pathway | CCL13, CXCL12, CCL18, JAK3, CX3CR1, CCL5, CCR2, CCR1, CXCL1, CXCL14, LYN, VAV1 | AL, HF, HPT, OB |
| hsa04060 | cytokine-cytokine receptor interaction | CCL13, CX3CR1, CCR1, CXCL14, CXCL12, CCL5, IL1B, OSM, CCR2, CXCL1, CCL18, TNF | AL, HF, HPT, OB |
| hsa04623 | cytokine DNA-sensing pathway | CCL5, IL1B, CASP1 | HF, HPT, SLS |
| hsa03320 | PPAR signaling pathway | FABP5, SORBS1, LPL | HC, SLS, DB |
| hsa04064 | NF-kappa B signaling pathway | CD14, BCL2A1, IL1B, TNF, LYN, CD14 | DB, HPT, ST |