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Temporal trend of therapy sequence of prevalent patients with combined prescriptions of S/V and SGLT2i. COVID-19 = coronavirus disease 2019, ESC = European Society of Cardiology, HF = heart failure, HFrEF = heart failure with reduced ejection fraction, SGLT2i = sodium-glucose co-transporter-2 inhibitor, S/V = sacubitril/valsartan.
