TABLE 2.
Virulence factors and genomic islands in six sequenced staphylococcal genomes
| Virulence factor |
S. aureus
|
S. epidermidis
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| COL
|
Mu50
|
N315
|
MW2
|
RP62a
|
ATCC 12228
|
|||||||
| Locus and gene | Island | Locus and gene | Island | Locus and gene | Island | Locus and gene | Island | Locus and gene | Island | Locus and gene | Island | |
| Enterotoxin | SA1657 sea | SAV2009 sec3 | vSa4 | SA1430 sead | MW1889 sea | φSa3 | ||||||
| SA0907 seb | vSa1 | SAV1824 seg | vSaβ | SA1817 sec3 | vSa4 | MW0759 sec2 | vSa3 | |||||
| SA0887 sei | vSal | SAV1828 sei | vSaβ | SA1642 seg | vSaβ | MW1937 seg | φSa3 | |||||
| SA0886 sek | vSal | SAV2008 sel | vSa4 | SA1646 sei | vSaβ | MW0051 seh | ||||||
| SAV1829 sem | vSaβ | SA1816 sel | vSa4 | MW0760 sel | vSa3 | |||||||
| SAV1825 sen | vSaβ | SA1647 sem | vSaβ | MW1938 sek | φSa3 | |||||||
| SAV1830 seo | vSaβ | SA1643 sen | vSaβ | MW0052 seod | ||||||||
| SAV1948 sep | φSa3 | SA1648 seo | vSaβ | |||||||||
| SAV1601 sep | SA1761 sep | φSa3 | ||||||||||
| SAV1827 seu | vSaβ | SA1645 yent1 | vSaβ | |||||||||
| SA1644 yent2 | vSaβ | |||||||||||
| Exotoxin | SA1178 set1 | vSaγ | SAV0422 set6 | vSaα | SA1009 set1 | vSaγ | MW1047 set1 | vSaγ | ||||
| SA0469 set1 | vSaα | SAV0423 set7 | vSaα | SA0357 set2 | MW1048 set4 | vSaγ | ||||||
| SA0468 set3 | vSaα | SAV0424 set8 | vSaα | SA1011 set3 | vSaγ | MW0382 set16 | vSaα | |||||
| SA0478 set3 | vSaα | SAV0425 set10 | vSaα | SA1010 set4 | vSaγ | MW0383 set17 | vSaα | |||||
| SA1180 set3 | vSaγ | SAV0426 set11 | vSaα | SA0382 set6 | vSaα | MW0384 set18 | vSaα | |||||
| SA0474 set4 | vSaα | SAV0427 set12 | vSaα | SA0383 set7 | vSaα | MW0385 set19 | vSaα | |||||
| SA1179 set4 | vSaγ | SAV1168 set12 | vSaγ | SA0384 set8 | vSaα | MW0386 set20 | vSaα | |||||
| SA0473 set5 | vSaα | SAV0428 set13 | vSaα | SA0385 set9 | vSaα | MW0387 set21 | vSaα | |||||
| SA0470 setd | vSaα | SAV0429 set14 | vSaα | SA0386 set10 | vSaα | MW0388 set22 | vSaα | |||||
| SA0472 setd | vSaα | SAV0433 set15 | vSaα | SA0387 set11 | vSaα | MW0389 set23 | vSaα | |||||
| SA0388 set12 | vSaα | MW0390 set24 | vSaα | |||||||||
| SA0389 set13 | vSaα | MW0391 set25 | vSaα | |||||||||
| SA0390 set14 | vSaα | MW0394 set26 | vSaα | |||||||||
| SA0393 set15 | vSaα | MW0345 setd | ||||||||||
| Exfoliative toxin | SA1184 etd | vSaγ | SAV1173 eta | vSaγ | SA1016 eta | vSaγ | MW1054 eta | vSaγ | ||||
| Toxic shock syn- drome toxin | SAV2011 tsst | vSa4 | SA1819 tsst | vSa4 | ||||||||
| Esterase | SA2345 | SAV2350d | SA2140d | MW2271d | SE1941 | SE1929 | ||||||
| SA2549d | SAV2535d | SA2323d | MW2456d | SE2109d | SE2095 | |||||||
| Serine protease | SA1869 splA | vSaβ | SAV1813 splA | vSaβ | SA1631 splA | vSaβ | MW1755 splA | vSaβ | ||||
| SA1868 splB | vSaβ | SAV1812 splB | vSaβ | SA1630 splB | vSaβ | MW1754 splB | vSaβ | |||||
| SA1867 splC | vSaβ | SAV1811 splC | vSaβ | SA1629 splC | vSaβ | MW1753 splC | vSaβ | |||||
| SA1866 splD | vSaβ | SAV1810 splD | vSaβ | SA1628 splD | vSaβ | MW1752 splF | vSaβ | |||||
| SA1865 splE | vSaβ | SAV1809 splF | vSaβ | SA1627 splF | vSaβ | MW0903 htrA | vSaβ | |||||
| SA1864 splF | vSaβ | SAV1023 htrA | SA0879 htrA | MW1670 htrA | ||||||||
| SA1028 htrA | SE2390 htrA | SE0722 htrA | ||||||||||
| SA1777 htrd | SE2401 | SE0723 | ||||||||||
| Staphylokinase | SAV1944 | φSa3 | SA1758 | φSa3 | MW1885 | φSa3 | ||||||
| Serine V8 protease | SA1057 sspA | SAV1048 sspA | SA0901 sspA | MW0932 sspA | SE1397 sspA | SE1543 sspA | ||||||
| Cysteine protease | SA1056 sspB | SAV1047 sspB | SA0900 sspB | MW0931 sspB | SE2390 sspB | SE0184 sspB | ||||||
| SA1970 sspB | SAV1046 sspC | SA0899 sspC | MW0930 sspC | SE2391 sspC | SE0183 sspC | |||||||
| SA1055 sspC | ||||||||||||
| Lipase | SA2694 lip | SAV2671 lip | SA2463 lip | MW2590 lip | SE2336 lip | SE0245 lip | ||||||
| SA0317 geh (amino)a | SAV0320 geh | SA0309 geh | MW0297 geh | SE0018 geh | SE2403 geh | |||||||
| SA0390 geh (carboxy)a | SE2297 geh1, gehC | SE0281 geh1, gehC | ||||||||||
| SE2388 geh2, gehD | SE0185 geh2, gehD | |||||||||||
| Lipase/esterase | SA0712 lipAd | SAV0655 lipAd | SA0610 lipAd | MW0617 lipAd | SE0309 lipA | SE0424 lipA | ||||||
| Extracellular elas- tasc precursor | SE2252 sepA | SE2219 sepA | ||||||||||
| Leukotoxin D | SA1880 lukD | vSaβ | SAV1819 lukD | vSaβ | SA1637 lukD | vSaβ | MW1767 lukD | vSaβ | ||||
| Leukotoxin E | SA1881 lukE | vSaβ | SAV1820 lukE | vSaβ | SA1638 lukE | vSaβ | MW1768 lukE | vSaβ | ||||
| Synergohymeno- tropic toxin | MW1379 lukSPV | φSa2 | ||||||||||
| Leukocidin F | SA1812 lukF | MW1378 lukFPV | φSa2 | |||||||||
| Leukocidin M | SA2006 lukM | SA1813 lukM | MW1942 lukM | |||||||||
| Alpha hemolysin | SA1173 hly | vSaγ | SAV1163 hly | vSaγ | SA1007 hly | vSaγ | MW0955 hly | vSaγ | ||||
| Beta hemolysin | SA2003 hlb | SAV2003 hlbe | SA1752 hlbe | MW1940 hlbe | SE2544 hlb | SE0008 hlb | ||||||
| Delta hemolysin | SA2022 hld | SAV2035 hld | SAS065 hld | MW1959 hld | SE1489 hld | SE1634 hld | ||||||
| Gamma hemolysin, component A | SA2419 hlgA | SAV2419 hlgA | SA2207 hlgA | MW2342 hlgA | ||||||||
| Gamma hemolysin, component C | SA2421 hlgC | SAV2420 hlgC | SA2208 hlgC | MW2343 hlgC | ||||||||
| Gamma hemolysin, component B | SA2422 hlgB | SAV2421 hlgB | SA2209 hlgB | MW2344 hlgB | ||||||||
| Hemolysin III | SA2160d | SAV2170 | SA1973d | MW2096d | SE1769d | SE1760d | ||||||
| Hemolysin | SA0762d | SAV0919 | SA0780d | MW0664d | SE2258d | SE2226d | ||||||
| Hyaluronate lyase | SA2194 hysA | SAV2202 hysA | SA2003 hysA | MW2129 hysA | ||||||||
| Thermonuclease nuclease | SA1357 nuc | SAV1324 nuc | SA1160 nuc | MW1211 nuc | SE0891 nuc | SE1004 nuc | ||||||
| SA0860 | SAV0815 | SA0746 | MW0769 | SE1570 | φSPβ | |||||||
| Cell wall hydrolase | SA1264 lytN | SAV1247 lytN | SA1090 lytN | MW1130 lytN | ||||||||
| Zinc metalloprotense | SA1281 | SAV1262 | SA1105 | MW1145 | SE0829d | SE0938d | ||||||
| Clp protease, proco- lytic subunit | SA0833 clpP | SAV0768 clpP | SA0723 clpP | MW0730 clpP | SE0436 clpP | SE0551 clpP | ||||||
| Clp protease, ATP binding subunit | SA0979 clpB | SAV0975 clpB | SA0835 clpB | MW0857 clpB | SE0564 clpB | SE0674 clpB | ||||||
| Clp protease, ATP binding subunit | SA1721 clpX | SAV1674 clpX | SA1498 clpX | MW1618 clpX | SE1238 clpX | SE1349 clpX | ||||||
| Clp protease, ATP binding subunit | SA0570 clpC | SAV0523 clpC | SA2336 clpC | MW2469 clpC | SE0165 clpC | SE0287 clpC | ||||||
| Staphylococcal protein A Spa | SA0095 spa | SAV0111 spa | SA0107 spa | MW0084 spa | ||||||||
| Phenol-soluble modulin | SA1186 beta | vSaγ | NT02SA1161 betab | vSaγ | NT01SA1111 betab | vSaγ | MW1056 beta | vSaγ | SE0736 beta1 | vSeγ | SE0846 beta1 | vSeγ |
| SA1187 beta | vSaγ | NT02SA1162 betab | vSaγ | NT01SA1112 betab | vSaγ | MW1057 beta | vSaγ | SE0737 beta1 | vSeγ | SE0847 beta1 | vSeγ | |
| SA2022 hldc | SAV2035 hldc | SAS065 hldc | MW2121 hldc | SE0738 beta1 | vSeγ | SE0848 beta1 | vSeγ | |||||
| SE0739 beta2 | vSeγ | SE0849 beta2 | vSeγ | |||||||||
| SE2397 beta1 | SE0177 beta | |||||||||||
| SE2400 beta1 | SE0174 beta1 | |||||||||||
| SE0083 alpha | ||||||||||||
| SE1489 deltac | SE1634 deltac | |||||||||||
a
geh in COL is disrupted by insertion of φCOL near the carboxy terminus of the protein.
b
Not in original annotation. NT02SA1161, NT025A1162, NT01SA1111, and NT01SA1112 were identified by TIGR annotation.
c
Also delta hemolysin.
d
Putative.
e
Truncated.