Table 2.

VBM and DBM Results

MNI peak (x,y,z)	Cluster level		k	Z	Brain region
	P FWE-corrected	Puncorrected
VBM CT+ Baseline > Follow-up
−28 45 44	0.002	0.030	46	6.19	Left dorsolateral prefrontal cortex (BA9)
−26 −80 −44	<0.001	0.004	90	5.04	Left cerebellum
VBM CT- Baseline > Follow-up
60 2 −32	0.001	0.013	63	5.56	Right middle temporal gyrus (BA21)
40 52 −15	0.002	0.039	41	5.30	Right anterior prefrontal cortex (BA10)
−2 −38 51	0.002	0.032	45	5.17	Left dorsal posterior cingulate cortex (BA 31)
−36 −68 −21	0.001	0.015	61	5.07	Left cerebellum
DBM CT+ Baseline > Follow-up
−27 51 27	<0.001	<0.001	1565	6.31	Left anterior prefrontal cortex (BA10)
27 42 28	<0.001	0.003	367	5.50	Right dorsolateral prefrontal cortex (BA9)
−48 34 15	0.002	0.042	149	5.14	Left dorsolateral prefrontal cortex (BA46)
DBM CT- Baseline > Follow-up
44 50 −15	0.002	0.047	141	5.10	Right anterior prefrontal cortex (BA10)
DBM NC reduction from Baseline to Follow-up Relative to CT+
−15 42 −18	0.001	0.020	202	5.54	Left orbitofrontal cortex (BA11)
24 12 −9	0.001	0.015	224	5.47	Right putamen

MNI=Montreal Neurological Institute coordinates; FWE=Family-wise error; k=cluster extent; VBM=Voxel-based morphometry; DBM=Deformation-based morphometry; BA=Brodmann Area; CT+=Breast cancer patients treated with chemotherapy; CT-=Breast cancer patients treated without chemotherapy; NC=Healthy controls with no cancer diagnosis