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| Intervention | Arm A (selpercatinib) |
Arm B (investigator's discretion of B1: cabozantinib or B2: vandetanib) | |
|---|---|---|---|
| Selpercatinib | Cabozantinib | Vandetanib† | |
| Dose | 160 mg | 140 mg | 300 mg |
| Schedule | BID continuously in 28-day cycles | QD continuously in 28-day cycles | QD continuously in 28-day cycles |
| Route | Oral | Oral | Oral |
Starting dose of vandetanib for patients with creatinine clearance <50 ml/min is 200 mg QD.
BID: Twice daily; QD: Once daily.
