Table 5.
Independent risk factors for the development of HBV-associated HCC.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| P -value | OR (95%CI) | P -value | OR (95%CI) | |
| FBXO43 (PMR ≤ 14.56%) | < 0.001 | 7.001 (3.725–13.159) | < 0.001 | 9.373 (3.745–23.459) |
| Male | 0.023 | 2.133 (1.111–4.096) | 0.024 | 3.125 (1.159–8.424) |
| Age (>50) | < 0.001 | 3.742 (2.063–6.789) | 0.003 | 3.793 (1.578–9.117) |
| HBsAg (>1,000 IU/ml) | < 0.001 | 0.189 (0.101–0.353) | 0.010 | 0.313 (0.130–0.756) |
| HBV–DNA (+) | < 0.001 | 0.060 (0.018–0.200) | < 0.001 | 0.038 (0.008–0.168) |
| AFP (>20 ng/ml) | < 0.001 | 4.363 (2.293–8.303) | 0.027 | 3.198 (1.145–8.929) |
| ALT (>50 U/L) | 0.769 | 0.911 (0.491–1.693) | – | – |
| AST (>40 U/L) | 0.116 | 1.589 (0.891–2.834) | – | – |
| PLT ( ≤ 100 × 109/L) | 0.001 | 7.816 (2.292–26.646) | 0.062 | 4.455 (0.930–21.337) |
| TBIL (>7.1 μmol/L) | 0.052 | 1.772 (0.996–3.151) | – | – |
| ALB ( ≤ 40 g/L) | < 0.001 | 3.824 (1.876–7.794) | 0.514 | 1.463 (0.467–4.585) |
| PTA ( ≤ 60%) | 0.068 | 0.145 (0.018–1.155) | – | – |
OR, odds ratio.