Table 2.
The summary of CNV-gene-AOD pairs in the causality network based on the physician’s overall cognitive diagnostic category at the time of death.
| CNV | Gene | Trait | Beta (CNV-Gene) | P.adj (CNV-Gene) | Beta (CNV-AOD) | P.adj (CNV-AOD) | Cor. coefficient (Gene-AOD) | P.adj (Gene-AOD) | P.adj_cit |
|---|---|---|---|---|---|---|---|---|---|
| DEL5006 | PLGRKT | AOD | 1.25E+00 | 1.71E-02 | 1.00E+01 | 2.19E-02 | 1.03E-01 | 3.27E-02 | 3.07E-02 |
| DUP42180 | OTOF | AOD | 1.15E+00 | 3.74E-02 | −8.99E+00 | 1.58E-02 | −1.65E-01 | 8.12E-04 | 3.85E-03 |
| mCNV14192 | PLAU | AOD | −1.52E+00 | 3.22E-03 | −1.05E+01 | 3.25E-03 | 1.33E-01 | 6.32E-03 | 3.81E-03 |
| DEL5006 | PLAU | AOD | 1.73E+00 | 4.28E-02 | 1.00E+01 | 2.19E-02 | 1.33E-01 | 6.32E-03 | 3.85E-03 |
| DUP42180 | SYTL2 | AOD | −9.63E-01 | 1.96E-02 | −8.99E+00 | 1.58E-02 | 1.04E-01 | 3.18E-02 | 2.72E-02 |
| DUP42180 | CALB2 | AOD | 1.77E+00 | 4.26E-02 | −8.99E+00 | 1.58E-02 | 1.35E-01 | 8.94E-03 | 1.28E-02 |
| DEL5006 | TLR1 | AOD | 2.45E+00 | 2.67E-02 | 1.00E+01 | 2.19E-02 | 1.52E-01 | 5.45E-03 | 3.85E-03 |
| mCNV14192 | TLR1 | AOD | −1.78E+00 | 2.04E-02 | −1.05E+01 | 3.25E-03 | 1.35E-01 | 5.45E-03 | 3.85E-03 |
| DEL5006 | NT5DC1 | AOD | 9.95E-01 | 4.89E-02 | 1.00E+01 | 2.19E-02 | 1.52E-01 | 1.82E-03 | 3.85E-03 |
| DEL5006 | PLGRKT | AOD | 1.25E+00 | 1.71E-02 | 1.00E+01 | 2.19E-02 | 1.03E-01 | 3.27E-02 | 3.07E-02 |
Beta (CNV-Gene), estimated effect size of CNV on gene expression; Beta (CNV-AOD), estimated effect size of CNV on age of death. P.adj, adjusted p-value calculated based on linear regression by Matrix eQTL and adjusted by FDR. P.adj_cit, the adjusted p-value from the Causal Inference Test with FDR correction. P.adj_cit < 0.05.