TABLE 3.
Ninety-seven ORFs identified as divergent or intermediate in the nonparatuberculosis MAC isolates MAA104, 6004, 6006, 6010, and 6058
| Region | ORF | Descriptiona | Functional category |
|---|---|---|---|
| MAP0034 | IS900 | IS element | |
| MAP_RD1 | MAP0097c | Acyl desaturase, N terminal | Lipid biosynthesis |
| MAP_RD1 | MAP0098c | Transcriptional regulator, TetR family | Conserved hypothetical |
| MAP_RD1 | MAP0100 | GPTase-activating protein | Conserved hypothetical |
| MAP_RD1 | MAP0101 | Conserved hypothetical protein | Conserved hypothetical |
| MAP_RD1 | MAP0102 | Hypothetical protein | Unknown |
| MAP_RD1 | MAP0103c | Hypothetical protein | Unknown |
| MAP_RD1 | MAP0106c | Integrase-recombinase | Phage-related function |
| MAP0159c | IS900 | IS element | |
| MAP0253 | ISmav2 | IS element | |
| MAP0284c | Hypothetical protein | Unknown | |
| MAP0338c | Similar to ISLp1 (GEN: AF386079) | IS element | |
| MAP0388 | Diarylpropane peroxidase | Conserved hypothetical | |
| MAP0428 | Similar to ISmav2 (GEN: AF286339) | IS element | |
| MAP0589c | Similar to ISmav2 (GEN: AF286339) | IS element | |
| MAP0664c | ISmav2 | IS element | |
| MAP0832c | Similar to IS1601-B | IS element | |
| MAP_RD2 | MAP0850c | Similar to ISmav2 (GEN: AF286339) | IS element |
| MAP_RD2 | MAP0851 | No hits | Unknown |
| MAP_RD2 | MAP0856c | No hits | Unknown |
| MAP_RD2 | MAP0859c | Mycobacterium phage L5 | Phage-related function |
| MAP_RD2 | MAP0866 | Integrase | Phage-related function |
| MAP1048c | Transposase (GEN: AF373840) | IS element | |
| MAP1287 | Similar to IS1601-B | IS element | |
| MAP1432 | REP family protein | REP13E12 family | |
| MAP1723 | Putative secreted protein | Cell envelope | |
| MAP1822c | Hypothetical protein | Unknown | |
| MAP1824c | Transposase (GEN: X58441) | IS element | |
| MAP1946 | Hypothetical protein | Unknown | |
| MAP1952c | Similar to IS1547 | IS element | |
| MAP2050 | Similar to IS1601-B | IS element | |
| MAP_RD3 | MAP2148 | Integrase-recombinase | Phage-related function |
| MAP_RD3 | MAP2153 | No hits | Unknown |
| MAP_RD3 | MAP2155 | Similar to IS6110 | IS element |
| MAP_RD3 | MAP2156 | Putative transposase (GEN: X52471) | IS element |
| MAP_RD3 | MAP2158 | No hits | Unknown |
| MAP_RD4 | MAP2179 | No hits | Unknown |
| MAP_RD4 | MAP2181c | No hits | Unknown |
| MAP_RD4 | MAP2183c | Linalool 8-monooxygenase | Conserved hypothetical |
| MAP_RD4 | MAP2184c | Short-chain alcohol dehydrogenase family | Energy metabolism |
| MAP_RD4 | MAP2185c | Proline-rich protein precursor | Unknown |
| MAP_RD4 | MAP2188c | Acyl-CoA synthase | Degradation |
| MAP_RD4 | MAP2189 | Cell invasion protein | Virulence |
| MAP_RD4 | MAP2190 | Part of mce4 operon | Virulence |
| MAP_RD4 | MAP2192 | Part of mce4 operon | Virulence |
| MAP_RD4 | MAP2193 | Part of mce3 operon | Virulence |
| MAP2302 | ISmav2 | IS element | |
| MAP2416c | Similar to ISLp1 (GEN: AF386079) | IS element | |
| MAP2427c | Probable hydrolase | Degradation | |
| MAP2566 | Similar to ISLp1 (GEN: AF386079) | IS element | |
| MAP_RD5 | MAP2755 | Hypothetical protein | Unknown |
| MAP_RD5 | MAP2756c | Hypothetical protein | Unknown |
| MAP_RD5 | MAP2758 | Hypothetical protein | Unknown |
| MAP_RD5 | MAP2759 | Conserved hypothetical protein | Conserved hypothetical |
| MAP_RD5 | MAP2764c | No hits | Unknown |
| MAP_RD5 | MAP2765c | No hits | Unknown |
| MAP_RD5 | MAP2767c | No hits | Unknown |
| MAP_RD5 | MAP2768c | PhiRV2 integrase | Phage-related function |
| MAP2963c | No hits | Unknown | |
| MAP2964c | Hypothetical protein | Unknown | |
| MAP3078c | Transposase (GEN: AF373840) | IS element | |
| MAP3357c | Similar to ISLp1 (GEN: AF386079) | IS element | |
| MAP3436c | Hypothetical protein | Unknown | |
| MAP3437c | No hits | Unknown | |
| MAP3467c | Similar to ISLp1 (GEN: AF386079) | IS element | |
| MAP_RD6 | MAP3726 | Iron ABC transporter | Transport-binding proteins |
| MAP_RD6 | MAP3727 | ABC transporter protein | Cell envelope |
| MAP_RD6 | MAP3729 | Dioxygenasediooxygenase | Energy metabolism |
| MAP_RD6 | MAP3731c | ABC transporter ATP-binding subunit | Transport-binding proteins |
| MAP_RD6 | MAP3732c | Cobalt permease and related transporters | Transport-binding proteins |
| MAP_RD6 | MAP3733c | Hypothetical protein | Unknown |
| MAP_RD6 | MAP3734c | ABC transporter ATP-binding protein | Cell envelope |
| MAP_RD6 | MAP3736c | Heavy metal tolerance protein | Conserved hypothetical |
| MAP_RD6 | MAP3738c | Conserved hypothetical protein | Conserved hypothetical |
| MAP_RD6 | MAP3739c | Possible sugar transporter | Cell envelope |
| MAP_RD6 | MAP3741 | Putative nonribosomal peptide synthase | Nonribosomal peptide synthesis |
| MAP_RD6 | MAP3742 | Putative nonribosomal peptide synthase | Nonribosomal peptide synthesis |
| MAP_RD6 | MAP3743 | Hypothetical protein | Unknown |
| MAP_RD6 | MAP3745 | Thioesterase | Conserved hypothetical |
| MAP_RD6 | MAP3747c | Conserved hypothetical protein | Conserved hypothetical |
| MAP_RD6 | MAP3748c | Similar to IS1110 | IS element |
| MAP_RD6 | MAP3751 | Conserved large membrane protein | Cell envelope |
| MAP_RD6 | MAP3753 | Hypothetical protein | Unknown |
| MAP_RD6 | MAP3754 | Similar to transposase of IS3 family | IS element |
| MAP_RD6 | MAP3755 | Similar to transposase | IS element |
| MAP_RD6 | MAP3762c | Possible rhamnosyl-glycosyl-transferase | Miscellaneous transferases |
| MAP_RD6 | MAP3764c | Polyketide synthase | Nonribosomal peptide synthesis |
| MAP_RD6 | MAP3766 | Membrane protein | Conserved hypothetical |
| MAP_RD6 | MAP3770 | Conserved hypothetical protein | Conserved hypothetical |
| MAP_RD6 | MAP3772c | Conserved hypothetical protein | Conserved hypothetical |
| MAP_RD6 | MAP3775c | Putative ABC transporter ATP-binding protein | Transport-binding proteins |
| MAP_RD7 | MAP3815 | No hits | Unknown |
| MAP_RD7 | MAP3816 | Hypothetical protein | Unknown |
| MAP_RD7 | MAP3817c | No hits | Unknown |
| MAP_RD7 | MAP3818 | Cytochrome P450 | Cytochrome P450 enzymes |
| MAP4270 | Multicopy phage resistance protein Mpr | Conserved hypothetical | |
| MAP4280 | Cholesterol oxidase | Degradation |
a
Abbreviations: GEN, GenBank sequence accession number; CoA, coenzyme A.