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. 2023 Nov 16;16:421. doi: 10.1186/s13071-023-06024-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3A–H — Differential expression of genes associated with glycolysis, the tricarboxylic acid cycle (TCA) cycle, pentose phosphate pathway (PPP), oxidative phosphorylation, reproduction, and DNA replication between Plasmodium falciparum 3D7^C580Y and P. falciparum 3D7^WT. A Heat map of DEGs associated with glycolysis (P. falciparum 3D7^C580Y/P. falciparum 3D7^WT) at different stages. B TCA cycle, C PPP, D oxidative phosphorylation, E reproduction-related genes, F and validation of reproduction-related genes through real-time polymerase chain reacion (PCR) and their interaction network. G Heat map of DEGs associated with DNA replication (P. falciparum 3D7^C580Y/P. falciparum 3D7^WT) at different stages. H Validation of DNA replication-related genes through real-time PCR and their interaction network. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001