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. 2005 Mar 14;33(5):1574–1580. doi: 10.1093/nar/gki295

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Structures of HR substrates. Each HR substrate contains a recipient neo regulated by the SV40 promoter and inactivated by an I-SceI site insertion. Donors lack a promoter and contain either the wild-type BanII site or a silent BsaI mutation in place of BanII. Distances (in kb) between neo repeats are indicated. Each neo repeat is 1.4 kb. (A) Triple repeat substrate. (B–D) Direct repeat substrates with increasing amounts of non-transcribed DNA between neo genes. (E) Direct repeat substrate with a transcriptionally active SVgpt gene between neo repeats.