Table 2.

PAI vs PNB

Year	Author	Type of study	Sample size	Method	Results
2020	Nicolino et al. (Nicolino et al. 2020)	Controlled, double-blinded, randomized	70	LIA with a saphenous nerve block (SNB) vs intra-articular cocktail	LIA with SNB was more effective in reducing pain after TKA (p = 0.001)
2018	Tong et al. (Tong et al. 2018)	A prospective single-center, double-blind, randomized controlled trial	40	LIA vs adductor canal block (ACB)	ACB was more effective in reducing total morphine consumption in the first 24 (p = 0.004) and 48 h (p = 0.03)
2018	Runge et al. (Runge et al. 2018)	A prospective single-center, double-blind, randomized controlled trial	82	PAI vs combined obturator nerve and femoral triangle blockade	Combined femoral triangle blockade was more effective in reducing morphine consumption (p < 0.001)
2019	Cicekci et al. (Cicekci et al. 2019)	A prospective single-center, double-blind, randomized controlled trial	79	PAI vs ACB	ACB was more effective in reducing morphine consumption (p < 0.005)
2020	Lützner et al. (Lützner et al. 2020)	Randomized, double-blind, placebo-controlled trial	140	Femoral nerve block, continuous sciatic nerve block, and single-shot obturator nerve block vs LIA with a continuous intraarticular catheter with ropivacaine	Femoral nerve block, continuous sciatic nerve block, and single-shot obturator nerve block were more effective in reducing morphine consumption (p < 0.05)
2019	Kostelnik et al. (2019)	Two-group randomized, controlled clinical trial	40	Single shot sciatic nerve block combined with adductor canal block with a catheter (CACB) vs LIA	Single-shot sciatic nerve block combined with CACB was more effective in reducing morphine consumption (p < 0.01)