. 2023 Nov 16;21(11):e08366. doi: 10.2903/j.efsa.2023.8366

Table E.1.

Summary of new in vitro genotoxicity study on Scansmoke SEF 7525 (SF‐004)

Name	Test system in vitro	Test object	Concentrations ^(a) and test conditions	Result	Reliability/comments	Relevance of test system/relevance of the result	Reference
Scansmoke SEF 7525	Micronucleus assay	Human TK6 cell line	20, 75, 150 μg/mL (3 + 24 h, +S9) 5, 10, 12.5 μg/mL (3 + 24 h, −S9) 2.5, 5, 12.5 μg/mL (24 h, −S9)	Positive	Reliable without restrictions. Study performed according to OECD TG 487 and in compliance with GLP.	High/High	BSRC, 2022a

Name

Test system in vitro

Test object

Concentrations ^(a) and test conditions

Result

Reliability/comments

Relevance of test system/relevance of the result

Reference

Scansmoke SEF 7525

Micronucleus assay

Human TK6 cell line

20, 75, 150 μg/mL (3 + 24 h, +S9)

5, 10, 12.5 μg/mL (3 + 24 h, −S9)

2.5, 5, 12.5 μg/mL (24 h, −S9)

Positive

Reliable without restrictions. Study performed according to OECD TG 487 and in compliance with GLP.

High/High

BSRC, 2022a

^(a)

The given concentrations are those for the cultures that were scored for micronuclei.