TABLE 1.

In silico clinical trial schedules of palbociclib

Schedule name	Schedule description
Current standard schedule	3 weeks on, 1 week off of 125 mg daily
Daily 100 mg	Continuous daily dosing of 100 mg
Daily 75 mg	Continuous daily dosing of 75 mg
BID 50 mg	Continuous daily dosing of 50 mg administered twice per day (100 mg in total)
BID 50 mg in the morning, 25 mg at night	Continuous daily dosing of 50 mg in the morning, 25 mg at night (75 mg in total)

NOTE: All palbociclib schedules are in combination with the current standard administration schedule for fulvestrant (500 mg intramuscular on days 1, 15, and 29, and then monthly thereafter).