Fig 4.

 Relative positions and nucleotide sequences of putative hormone response elements (HREs) within intron E of FKBP5. (A) Solid boxes represent exons 1 to 11 and horizontal lines represent the 5′ promoter and introns A to J of FKBP5. The positions of pIE1 and pIE2 within intron E are indicated by arrows. FKBP5 spans approximately 115 kb; introns are drawn to scale, but exons are not (average size of exons 1 to 10 is 0.1 kb, whereas exon 11 is >1.2 kb). (B) The consensus HRE is shown at top in bold with half-sites underlined. HRE half-sites within pIE1 and pIE2 are shown in upper case. The sequences of HRE-like regions in pIE1 and pIE2 of intron E of human FKBP5 are derived from human chromosome 6 (GenBank accession number NT_007592, nucleotides 26375999 to 26375965 and 26367010 to 26366976, respectively), of rat FKBP5 from rat chromosome 20 (NW_047597, nucleotides 3272063 to 3272029 and 3267890 to 3267856, respectively), and of mouse FKBP5 from mouse chromosome 17 (NT_039649, nucleotides 5002533 to 5002499 and 4998218 to 4998184, respectively). Bases that are conserved between human, rat, and mouse sequences are indicated with dashed lines