Table 1.
Antigen | Allele | Start | End | Length | Peptide | Adjusted rank | IFN-γ scores | Antigenicity Scores | Immunogenicity score | ABC Score |
---|---|---|---|---|---|---|---|---|---|---|
HTL | ||||||||||
Ag85A | HLA-DQA1*06:01,DQB1*03:03 | 161 | 178 | 18 | TGSAVVGLSMAASSALTL | 0.36 | 1.1333726 | 0.8765 | NA | NA |
Ag85B | HLANADQA1*03:01,DQB1*06:01 | 161 | 177 | 17 | AAIGLSMAGSSAMILAA | 0.49 | 1.1091804 | 0.7215 | NA | NA |
CFP10 | HLANADQA1*03:01,DQB1*06:01 | 74 | 86 | 13 | TNIRQAGVQYSRA | 0.31 | 0.61651125 | 0.7348 | NA | NA |
MPT51 | HLANADQA1*03:01,DQB1*06:01 | 145 | 158 | 14 | AQGGYGAMALAAFH | 0.33 | 0.024282193 | 0.8205 | NA | NA |
Mpt64 | HLANADRB3*02:02 | 45 | 62 | 18 | MSDPAYNINISLPSYYPD | 0.38 | 1.024208 | 1.0403 | NA | NA |
MTB8.4 | HLANADQA1*05:01,DQB1*03:01 | 7 | 23 | 17 | ALSAGVGAVAMSLTVGA | 0.43 | 0.59925408 | 0.9526 | NA | NA |
MTB32A | HLANADPA1*01,DPB1*04:01 | 5 | 20 | 16 | RRRSLRWSWLLSVLAA | 0.43 | 0.59880927 | 1.2614 | NA | NA |
PPE18 | HLANADQA1*01:02,DQB1*06:02 | 84 | 101 | 18 | AELTAAQVRVAAAAYETA | 0.18 | 1.0131456 | 0.7988 | NA | NA |
PPE44 | HLANADQA1*03:01,DQB1*06:01 | 152 | 167 | 16 | YGYAAASAVAARLNPL | 0.02 | 0.69654642 | 0.7955 | NA | NA |
PPE44 | HLANADQA1*05:01,DQB1*03:01 | 270 | 287 | 18 | GTVGGAAPGGGAAAAVAH | 0.03 | 1.148739 | 1.5999 | NA | NA |
PPE68 | HLANADQA1*03:01,DQB1*06:01 | 304 | 319 | 16 | VAPSVMPAAAAGSSAT | 0.31 | 0.23735279 | 1.0173 | NA | NA |
RpfA | HLANADQA1*05:01,DQB1*03:01 | 21 | 34 | 14 | TGAVLGGGGIAMAA | 0.03 | 0.51780631 | 0.7682 | NA | NA |
RpfB | HLANADQA1*05:01,DQB1*03:01 | 9 | 24 | 16 | LLLVLAFAGGYAVAAC | 0.12 | 0.26811457 | 0.7437 | NA | NA |
CTL | ||||||||||
Ag85A | HLANAC*03:04 | 162 | 170 | 9 | GSAVVGLSM | NA | NA | 1.0016 | 0.02032 | NA |
Ag85B | HLANAB*15:11 | 285 | 294 | 10 | NAAGGHNAV | NA | NA | 1.9957 | 0.12765 | NA |
CFP10 | HLANAA*33:03 | 49 | 57 | 9 | TAAQAAVVR | NA | NA | 0.7677 | 0.03003 | NA |
MPT51 | HLANAA*02:01 | 289 | 297 | 9 | AMSGDIVGA | NA | NA | 1.0252 | 0.18192 | NA |
Mpt63 | HLANAA*11:01 | 99 | 107 | 9 | RTADGINYR | NA | NA | 1.8872 | 0.18568 | NA |
MTB32A | HLANAC*03:04 | 141 | 149 | 9 | AAIGGGVAV | NA | NA | 1.3251 | 0.1999 | NA |
PPE18 | HLANAC*01:02 | 158 | 166 | 9 | ATATATATL | NA | NA | 1.0012 | 0.1821 | NA |
PPE44 | HLANAA*02:01 | 232 | 241 | 10 | FLNLDVPLFV | NA | NA | 1.3663 | 0.09714 | NA |
PPE68 | HLANAC*03:04 | 155 | 163 | 9 | QAETAVNTL | NA | NA | 0.875 | 0.16574 | NA |
RpfA | HLANAC*03:04 | 141 | 149 | 9 | AVNGEPAPL | NA | NA | 1.1393 | 0.1456 | NA |
RpfA | HLANAA*02:01 | 117 | 126 | 10 | GLSNATPREV | NA | NA | 1.0472 | 0.10743 | NA |
RpfB | HLANAA*30:01 | 191 | 199 | 9 | QVTRNRIKK | NA | NA | 0.7561 | 0.09342 | NA |
RpfE | HLANAC*01:02 | 73 | 82 | 10 | NLPPPLAPDF | NA | NA | 1.441 | 0.00407 | NA |
B cell | ||||||||||
Ag85A | NA | 269 | 288 | 20 | AKFLEGFVRTSNIKFQDAYN | NA | NA | NA | NA | 0.91 |
CFP21 | NA | 178 | 197 | 20 | APDDPICTGGGNIMAHVSYV | NA | NA | NA | NA | 0.91 |
EspA | NA | 256 | 275 | 20 | AGLSASSGLAHADSLASSAS | NA | NA | NA | NA | 0.9 |
MPT51 | NA | 243 | 262 | 20 | IGQAAEAMGNSRMFYNQYRS | NA | NA | NA | NA | 0.93 |
MTB32A | NA | 175 | 194 | 20 | ALGQTVQASDSLTGAEETLN | NA | NA | NA | NA | 0.89 |
PPE68 | NA | 160 | 179 | 20 | VNTLFEKLEPMASILDPGAS | NA | NA | NA | NA | 0.91 |
RpfA | NA | 97 | 116 | 20 | AVGERVLATQGRGAWPVCGR | NA | NA | NA | NA | 0.92 |
TB10.4 | NA | 68 | 87 | 20 | AYHAMSSTHEANTMAMMARD | NA | NA | NA | NA | 0.86 |
NA, not applicable.