Skip to main content
. 2023 Nov 2;14:1280299. doi: 10.3389/fimmu.2023.1280299

Table 1.

The immunodominant HTL, CTL, and B-cell epitopes were selected to construct the PP13138R vaccine.

Antigen Allele Start End Length Peptide Adjusted rank IFN-γ scores Antigenicity Scores Immunogenicity score ABC Score
HTL
Ag85A HLA-DQA1*06:01,DQB1*03:03 161 178 18 TGSAVVGLSMAASSALTL 0.36 1.1333726 0.8765 NA NA
Ag85B HLANADQA1*03:01,DQB1*06:01 161 177 17 AAIGLSMAGSSAMILAA 0.49 1.1091804 0.7215 NA NA
CFP10 HLANADQA1*03:01,DQB1*06:01 74 86 13 TNIRQAGVQYSRA 0.31 0.61651125 0.7348 NA NA
MPT51 HLANADQA1*03:01,DQB1*06:01 145 158 14 AQGGYGAMALAAFH 0.33 0.024282193 0.8205 NA NA
Mpt64 HLANADRB3*02:02 45 62 18 MSDPAYNINISLPSYYPD 0.38 1.024208 1.0403 NA NA
MTB8.4 HLANADQA1*05:01,DQB1*03:01 7 23 17 ALSAGVGAVAMSLTVGA 0.43 0.59925408 0.9526 NA NA
MTB32A HLANADPA1*01,DPB1*04:01 5 20 16 RRRSLRWSWLLSVLAA 0.43 0.59880927 1.2614 NA NA
PPE18 HLANADQA1*01:02,DQB1*06:02 84 101 18 AELTAAQVRVAAAAYETA 0.18 1.0131456 0.7988 NA NA
PPE44 HLANADQA1*03:01,DQB1*06:01 152 167 16 YGYAAASAVAARLNPL 0.02 0.69654642 0.7955 NA NA
PPE44 HLANADQA1*05:01,DQB1*03:01 270 287 18 GTVGGAAPGGGAAAAVAH 0.03 1.148739 1.5999 NA NA
PPE68 HLANADQA1*03:01,DQB1*06:01 304 319 16 VAPSVMPAAAAGSSAT 0.31 0.23735279 1.0173 NA NA
RpfA HLANADQA1*05:01,DQB1*03:01 21 34 14 TGAVLGGGGIAMAA 0.03 0.51780631 0.7682 NA NA
RpfB HLANADQA1*05:01,DQB1*03:01 9 24 16 LLLVLAFAGGYAVAAC 0.12 0.26811457 0.7437 NA NA
CTL
Ag85A HLANAC*03:04 162 170 9 GSAVVGLSM NA NA 1.0016 0.02032 NA
Ag85B HLANAB*15:11 285 294 10 NAAGGHNAV NA NA 1.9957 0.12765 NA
CFP10 HLANAA*33:03 49 57 9 TAAQAAVVR NA NA 0.7677 0.03003 NA
MPT51 HLANAA*02:01 289 297 9 AMSGDIVGA NA NA 1.0252 0.18192 NA
Mpt63 HLANAA*11:01 99 107 9 RTADGINYR NA NA 1.8872 0.18568 NA
MTB32A HLANAC*03:04 141 149 9 AAIGGGVAV NA NA 1.3251 0.1999 NA
PPE18 HLANAC*01:02 158 166 9 ATATATATL NA NA 1.0012 0.1821 NA
PPE44 HLANAA*02:01 232 241 10 FLNLDVPLFV NA NA 1.3663 0.09714 NA
PPE68 HLANAC*03:04 155 163 9 QAETAVNTL NA NA 0.875 0.16574 NA
RpfA HLANAC*03:04 141 149 9 AVNGEPAPL NA NA 1.1393 0.1456 NA
RpfA HLANAA*02:01 117 126 10 GLSNATPREV NA NA 1.0472 0.10743 NA
RpfB HLANAA*30:01 191 199 9 QVTRNRIKK NA NA 0.7561 0.09342 NA
RpfE HLANAC*01:02 73 82 10 NLPPPLAPDF NA NA 1.441 0.00407 NA
B cell
Ag85A NA 269 288 20 AKFLEGFVRTSNIKFQDAYN NA NA NA NA 0.91
CFP21 NA 178 197 20 APDDPICTGGGNIMAHVSYV NA NA NA NA 0.91
EspA NA 256 275 20 AGLSASSGLAHADSLASSAS NA NA NA NA 0.9
MPT51 NA 243 262 20 IGQAAEAMGNSRMFYNQYRS NA NA NA NA 0.93
MTB32A NA 175 194 20 ALGQTVQASDSLTGAEETLN NA NA NA NA 0.89
PPE68 NA 160 179 20 VNTLFEKLEPMASILDPGAS NA NA NA NA 0.91
RpfA NA 97 116 20 AVGERVLATQGRGAWPVCGR NA NA NA NA 0.92
TB10.4 NA 68 87 20 AYHAMSSTHEANTMAMMARD NA NA NA NA 0.86

NA, not applicable.