Fig 2.

Macrophages elicit an alternative carbon metabolism-driven transcriptional response shared with other Candida species. (A) Principal component analysis distinguishes C. auris incubated with macrophages from those in medium-only conditions. The percentage of variance explained by each of the first two principal components is indicated. (B) Gene Set Enrichment Analysis for GO terms significantly associated with shifts in log₂-fold change (false discovery rate = 0.1). Positive and negative normalized enrichment scores reflect GO terms induced and repressed during phagocytosis, respectively. (C) Volcano plot of the phagocytosis response. Genes in the previously determined conserved induced gene set are in red, with select highly induced genes labeled.