Table 1.
Patient demographic and disease characteristics
| Parameter | GIL + AZA (n = 74) | AZA (n = 49) |
|---|---|---|
| Sex, n (%) | ||
| Male | 42 (56.8) | 28 (57.1) |
| Female | 32 (43.2) | 21 (42.9) |
| Race, n (%) | ||
| White | 46 (62.2) | 29 (59.2) |
| Asian | 20 (27.0) | 13 (26.5) |
| Age, y | ||
| Mean ± standard deviation | 77.4 ± 5.6 | 76.7 ± 5.3 |
| Median (minimum, maximum) | 78.0 (59, 90) | 76.0 (61, 88) |
| Age group, n (%)∗ | ||
| <75 y | 21 (28.4) | 13 (26.5) |
| ≥75 y | 53 (71.6) | 36 (73.5) |
| Body surface area, m2 | ||
| n | 73 | 47 |
| Mean ± standard deviation | 1.75 ± 0.22 | 1.75 ± 0.25 |
| Median (minimum, maximum) | 1.72 (1.4, 2.7) | 1.72 (1.2, 2.5) |
| Baseline ECOG PS, n (%) | ||
| 0-1 | 38 (51.4) | 32 (65.3) |
| ≥2 | 35 (47.3) | 16 (32.7) |
| Missing | 1 (1.4) | 1 (2.0) |
| Baseline FLT3 mutation type, n (%) | ||
| ITD alone | 58 (78.4) | 40 (81.6) |
| TKD (D835/I836) alone | 14 (18.9) | 7 (14.3) |
| ITD with TKD (D835/I836) | 2 (2.7) | 2 (4.1) |
| Baseline FLT3 mutation status, n (%)∗ | ||
| ITD allelic ratio < 0.5 | 25 (33.8) | 18 (36.7) |
| ITD allelic ratio ≥ 0.5 | 35 (47.3) | 24 (49.0) |
| TKD | 14 (18.9) | 7 (14.3) |
| Cytogenetic risk status, n (%)∗,† | ||
| Favorable | 2 (2.7) | 0 |
| Intermediate | 51 (68.9) | 36 (73.5) |
| Unfavorable | 8 (10.8) | 5 (10.2) |
| Others (unknown, missing) | 13 (17.6) | 8 (16.3) |
Unknown category includes missing and data not allowed to be collected.
∗
Stratification factors for analysis.
†
Patients may have reported more than one cytogenetic risk status.