Table 1. Tissue Distribution of Radioactivity in Mice after Intravenous Injection of [11C]Clorgyline, 2-[18F]Fluoroethyl-harmol, and [11C]Harminea.
| tissue | % ID/g 20 min [11C]clorgyline | % ID/g 225 min 2-[18F]fluoroethyl-harmol | % ID/g
90 min [11C]harmine |
|
|---|---|---|---|---|
| LNCaP (n = 4) | LNCaP (n = 3) | LNCaP (n = 4) | PC3 (n = 3) | |
| blood | 1.8 ± 0.4 | 1.5 ± 0.3 | 1.3 ± 0.3 | 1.5 ± 0.5 |
| liver | 5.5 ± 0.6 | 1.3 ± 0.01 | 4.8 ± 1.0 | 4.4 ± 1.0 |
| heart | 2.2 ± 0.5 | 1.9 ± 0.04 | 1.8 ± 0.4 | 1.2 ± 0.1 |
| lung | 8.2 ± 2.8 | 7.2 ± 0.3 | 3.7 ± 0.5 | 2.8 ± 0.3 |
| kidney | 7.2 ± 1.5 | 4.0 ± 0.7 | 6.1 ± 1.0 | 3.9 ± 0.5 |
| muscle | 1.5 ± 0.2 | 1.6 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.2 |
| tumor | 2.7 ± 0.5 | 3.2 ± 0.8 | 3.7 ± 0.5 | 1.3 ± 0.2 |
| brain | 3.4 ± 1.3 | 5.9 ± 0.2 | 4.7 ± 0.8 | 3.1 ± 0.6 |
| T/M | 1.8 ± 0.2 | 2.0 ± 0.4 | 3.6 ± 0.7 | 1.6 ± 0.3 |
a
Mean % injected dose ± SD per gram of tissue of n animals. T/M: tumor/muscle uptake.