Figure 1.
Tet2 loss accelerates the development of TFH-like lymphomas in all immune cells. (A) Characteristics of the 2 genotypes. (B) Overall survival of mice with the 2 genotypes. ∗∗∗P value < .005; n.s., not significant. (C) Cumulative incidence of engraftment in nude mice injected in 6 different suspensions. ∗P value < .05. (D) Overview of scRNA-seq in spleen cells; MxTR, n = 2; and MxWT, n = 2. (E) UMAP plot after integration of data from spleen cells of MxTR and MxWT. Three cell types are indicated by dashed lines. Bar graphs indicating the (F) numbers and (G) proportions of cells in each cluster. (H) UMAP plots showing reclustering of mB5 cluster. The bar graphs show (I, left) the number of cells and (J, right) the percentages in each cluster. (K) GSVA with GCB-related gene sets for each mB5 subcluster. (L) Stacked violin plot split and (M) feature plots showing GCB markers. ∗Genes highly expressed in GCB1 to 3 of MxTR compared to those of MxWT.