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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Pathol. 2023 Sep 21;261(3):361–371. doi: 10.1002/path.6194

Figure 3. Proteomic analysis of differentially expressed proteins between experimental groups.

Figure 3.

(A) Volcano Plot. Proteins are plotted as -log10(P-value) versus log2 Fold-Change. (B) Venn diagrams showing common and unique altered proteins between experimental groups. (C) Top 10 pathways downregulated by rolipram, (D) upstream regulatory analysis of rolipram-regulated proteins, (E) Western blot for liver pMLC and (F) Endothelin 1 (ET-1). VC – vehicle control, CCl4 – carbon tetrachloride, Rol+CCl4 – Rolipram-cotreated CCl4 mice. GAPDH – loading control. One-way ANOVA with Tukey’s post hoc test, *p<0.05, **p<0.01, ****p<0.0001 compared to vehicle control group (VC), ap<0.05 compared to CCl4.