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. 2004 Dec 14;7(2):R196–R207. doi: 10.1186/ar1472

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Copyright © 2004 Adarichev et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gene activities at different phases of arthritis progression. All clusters identified in pre-inflamed joints (PA/AN comparison, yellow circles), acute arthritis (AA/AN, red circles), and chronic arthritic paws (CA/AN, blue circles) are indicated by the number of genes in the cluster (circle diameter represents cluster size) and the average fold change of gene expression (logarithmic horizontal scale). The size of the cluster varies from 3 genes ('complement cascade' cluster) in pre-inflamed joints to 51 genes ('immune response' cluster) in acute arthritis. AN, normal paws of naive BALB/c^SCIDmice; PA, clinically normal pre-arthritic paws; AA, acutely arthritic paws; CA, chronically inflamed paws.