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Hierarchical clustering (left) and expression patterns (A–F) for 37 early arthritis genes (listed in Table 2) differentially expressed in pre-inflamed (PA) joints of recipient BALB/cSCID mice. Gene expression was compared with normal paws (AN) of naive BALB/cSCID mice (PA/AN comparison, with a cut-off threshold at twofold change). The expression profiles of these 37 signature genes are shown for each phase of the disease (PA, acute [AA], or chronic [CA]) and also in normal paws.
