Table 2.
Transmission disequilibrium test analysis of the US and UK systemic onset juvenile rheumatoid arthritis families using Transmit
| Arg260 transmission | Thr260 transmission | ||||||
| SoJRA families | n | Observed | Expected | Observed | Expected | χ2 (1 df) | P |
| US only | 82 | 99 | (88.0) | 65 | (75.9) | 6.0* | 0.01* |
| US unaffected siblings | 79 | 82 | (77.5) | 76 | (80.5) | 1.04 | 0.3 |
| UK only | 74 | 91 | (89.0) | 57 | (58.0) | 0.08 | 0.78 |
| UK and US together | 156 | 190 | (177.8) | 122 | (134.2) | 4.2* | 0.04* |
*Significant findings. n, number of informative families for transmission; UK, British Paediatric Rheumatology Study Group cohort; US, Cincinnati cohort.