Table 5.

Associations between prenatal exposure measured in cord serum and behavior scores at age 12 y. Results from the single-pollutant approach, PELAGIE mother–child cohort, Brittany, France ($n=444$).

Outcome	Exposure
	PFOA (${\log }_2$ $\mathrm{\mu }\mathrm{g}/\mathrm{L}$) $n=444$ aMR (95% CI)	PFNA (${\log }_2$ $\mathrm{\mu }\mathrm{g}/\mathrm{L}$) $n=433$ aMR (95% CI)	PFDA (${\log }_2$ $\mathrm{\mu }\mathrm{g}/\mathrm{L}$) $n=406$ aMR (95% CI)	PFUnDA (${\log }_2$ $\mathrm{\mu }\mathrm{g}/\mathrm{L}$) $n=422$ aMR (95% CI)	PFHxS (${\log }_2$ $\mathrm{\mu }\mathrm{g}/\mathrm{L}$) $n=444$ aMR (95% CI)	PFOS (${\log }_2$ $\mathrm{\mu }\mathrm{g}/\mathrm{L}$) $n=444$ aMR (95% CI)
Main analysis
SDQ externalizing	1.18 (1.03, 1.34)	1.14 (1.00, 1.29)	1.07 (0.94, 1.21)	1.00 (0.88, 1.13)	1.02 (0.90, 1.16)	1.06 (0.94, 1.21)
SDQ hyperactivity	1.20 (1.04, 1.40)	1.18 (1.02, 1.36)	1.11 (0.96, 1.30)	0.99 (0.85, 1.14)	1.07 (0.93, 1.23)	1.08 (0.94, 1.26)
DIA internalizing	1.05 (0.96, 1.14)	1.08 (1.00, 1.17)	1.11 (1.02, 1.21)	1.06 (0.97, 1.15)	1.02 (0.94, 1.10)	1.02 (0.94, 1.11)
DIA anxiety	1.06 (0.98, 1.16)	1.10 (1.01, 1.19)	1.11 (1.02, 1.21)	1.07 (0.98, 1.16)	1.02 (0.94, 1.11)	1.01 (0.93, 1.10)
DIA depression	1.08 (0.97, 1.21)	1.11 (1.00, 1.23)	1.14 (1.01, 1.27)	1.05 (0.95, 1.17)	1.02 (0.92, 1.13)	1.02 (0.92, 1.14)
Complementary analysis
DIA externalizing	1.05 (0.94, 1.17)	1.03 (0.93, 1.14)	1.13 (1.01, 1.27)	1.04 (0.94, 1.16)	1.03 (0.93, 1.14)	1.00 (0.90, 1.11)
DIA ADHD	1.07 (0.96, 1.19)	1.06 (0.96, 1.18)	1.16 (1.04, 1.30)	1.05 (0.95, 1.16)	1.06 (0.96, 1.17)	1.03 (0.92, 1.14)
SDQ internalizing	1.06 (0.94, 1.20)	0.94 (0.84, 1.05)	0.97 (0.86, 1.09)	0.95 (0.85, 1.06)	1.04 (0.93, 1.17)	1.00 (0.88, 1.13)

Note: Negative binomial regression models adjusted for maternal age at the beginning of pregnancy (in years), maternal prepregnancy BMI (in three categories: $<18.5\mathrm{kg}/\mathrm{m}²$, $18.5–25\mathrm{kg}/\mathrm{m}²$, $\ge 25\mathrm{kg}/\mathrm{m}²$), maternal education (in three groups: $<12$ y, 12 y, $>12$ y), parity (nulliparous vs. multiparous), maternal prepregnancy fish intake ($<1$ once/month, at least once a month, at least twice a week) smoking status at inclusion (smoker vs. nonsmoker) and child sex. ADHD, attention-deficit/hyperactivity disorder; aMR, adjusted mean ratio; BMI, body mass index; CI, confidence interval; DIA, Dominic Interactive for Adolescents; PFDA, perfluorodecanoic acid; PFHxS, perfluorohexanesulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid; PFUnDA, perfluoroundecanoic acid; SDQ, Strengths and Difficulties Questionnaire.