FIGURE 3.

Concordance statistic for prediction of event-free survival in children with Alagille syndrome treated with maralixibat, according to demographics, and clinical and laboratory characteristics. Variables selected for inclusion in the model (ie, those with a concordance statistic ≥0.7) were total bilirubin levels at W48, change in pruritus (as assessed by ItchRO[Obs]) from baseline to W48, sBA (total serum bile acids) levels at W48, and age at enrollment. Abbreviations: ALP, alkaline phosphatase; APRI, AST to platelet ratio index; BL, baseline; ItchRO(Obs), Itch-Reported Outcome (Observer); PedsQL, Pediatric Quality of Life Inventory^TM 4.0 Generic Core Scales; sBA, serum bile acids; W48, week 48.