TABLE 1.
Clinical and laboratory characteristics
| Clinical and laboratory characteristics | Baseline (N = 76) | Week 48 (N = 76) |
|---|---|---|
| ItchRO(Obs) scorea | 2.7 (2.1, 3.1) | 1.14 (0.24, 1.86) |
| Weight z-score | −1.41 (−2.15, −0.67) | −1.40 (−2.05, −0.63) |
| Height z-score | −1.50 (−2.29, −0.95) | −1.45 (−2.35, −0.81 |
| Total bilirubin (mg/dL) | 2.3 (0.9, 8.4) | 2.0 (0.9, 8.1) |
| Direct bilirubin (mg/dL) | 1.7 (0.6, 7.0) | 1.7 (0.6, 6.8) |
| sBA (μmol/L) | 184 (78, 361) | 100 (43, 194) |
| Albumin (g/dL) | 4.6 (4.3, 4.7) | 4.6 (4.3, 4.7) |
| ALT (U/L) | 134 (95, 193) | 181 (125, 237) |
| AST (U/L) | 130 (96, 185) | 155 (110, 209) |
| GGT (U/L) | 392 (188, 751) | 418 (285, 663) |
| International normalized ratio | 1.00 (1.00, 1.10) | 1.00 (1.00, 1.10) |
| Platelets (×109/L) | 293 (223, 383) | 252 (195, 346) |
Note: All data are median (Q1, Q3).
a
ItchRO(Obs) score recorded as weekly morning average.
Abbreviations: GGT, gamma-glutamyl transferase; ItchRO(Obs), Itch-Reported Outcome (Observer); sBA, serum bile acids.