Table 3.

Anti-influenza virus activity and cytotoxicity of selected compounds in MDCK cells.

		EC50 a values (μM) towards influenza viruses
Compounds.	R	H1N1 c	H3N2 d	CC50 (μM) b
		group-1	group-2
6g		0.03 ± 0.03	0.16 ± 0.08	>250
6i		0.03 ± 0.03	0.32 ± 0.08	>250
6j		0.03 ± 0.02	0.80 ± 0.003	>250
6k		0.02 ± 0.01	0.12 ± 0.03	>250
OSC	–	0.02 ± 0.01	0.36 ± 0.16	>250
ZA	–	0.009 ± 0.002	0.27 ± 0.03	>250

^aEC₅₀: compound concentration that inhibits 50% of virus plaque formation in MDCK cells infected with influenza A viral strains, presented as the mean ± SD and determined by the PRA method.

^bCC₅₀: concentration required to reduce the viability of mock-infected cell cultures by 50%, as determined by the MTT method.

^cA/PR/8/34.

^dA/Wisconsin/67/05.