Table 1.
Presentation and markers of gut microbiota modulating on TAMs in different tumors.
| Types of Cancer | Keystone microbiota | The appearance in the tumor | Diagnosis marker | Reference |
|---|---|---|---|---|
| CRC | Bifidobacterium and Lactobacillus | Decrease | 91 | |
| CRC | Enteric dysbacteriosis; Bacteroides And Bacillus |
The infiltration rate of M2 macrophages is increased | SATB2 | 92 |
| HCC | Enteric dysbacteriosis | Secretes IL-25, induces M2 macrophage polarization and accelerates tumor growth | 53 | |
| HCC |
Bifidobacterium; Klebsiella and Prevotella |
Bifidobacterium decrease; Klebsiella and Prevotella increase | 93 | |
| HCC | Escherichia coli 541–15 | Decrease in TAMs and MDSC levels after colonization, and slowing adenoma growth | 94 | |
| CRC | Clostridium nucleatum, anaerobes, P. micra, E. cordens and X. perforans | Increase | L-Alanine, Glycine, L-Valine, Myristic acid | 95 |
| CRC | Enteric dysbacteriosis | CTSK | 86 | |
| CRC | Enteric dysbacteriosis | β-catenin | 96 | |
| Lung Cancer | Firmicutes and Bacteroides SPP | The lactate content within the tumor is greatly increased, contributing to M2-type polarization | MCT-2 | 97 |
| CRC | Atopobium vaginae, Selenomonas sputgena and Faecalibacterium prausnitzii | Positive association with poor prognosis | Atopobium vaginae, Selenomonas sputgena and Faecalibacterium prausnitzii | 98 |