Table III.

Sensitivity to ACCase inhibitors of and amino acids present at specific positions in ACCase from 10 eukaryotic organisms

I₅₀ values correspond to APP or CHD concentrations inhibiting 50% ACCase activity.

Organism	Accession No.	Range of I50 Values		Amino Acid Present at Position									References for I50 Values
		APPs	CHDs	1,781	2,027	2,037	2,041	2,078	2,079	2,080	2,088	2,096
		μm
Black-grass cpa	AJ310767	0.06–4.0	0.7–9.0	Ile	Trp	Leu	Ile	Asp	Ser	Lys	Cys	Gly	Price et al. (2004); Menéndez and De Prado (1999); This work
Rye-grass cpa	AF359515, AJ519781	0.2–0.6	4.2	.b	.	.	.	.	.	.	.	.	Evenson et al. (1997); Christopher and Holtum (1998); Kuk et al. (2000)
Wheat cpa	AF029895	0.2–2.0	<10.0	.	.	.	.	.	.	.	Phe	.	Gornicki and Haselkorn (1993); Konishi and Sasaki (1994); Joachimiak et al. (1997)
Maize cpa	U19183	0.04–10.0	10.0	.	.	.	.	.	.	.	.	.	Egli et al. (1993); Herbert et al. (1996); Price et al. (2003)
Green foxtail cpa	AF294805	0.08–4.4	0.3–7.7	.	.	.	.	.	.	.	.	.	Marles et al. (1993); Shukla et al. (1997)
Black-grass cya	AJ632096	35.0	NAc	Leu	.	.	.	.	.	.	Met	.	Menéndez and De Prado (1999)
Wheat cya	U39321	250.0	250.0–>500.0	Leu	.	.	.	.	.	.	Met	.	Joachimiak et al. (1997)
Pea cya	L25042d	7.0–150.0	>1,000.0	Leu	.	.	.	.	.	Arg	Met	.	Alban et al. (1994); Konishi and Sasaki (1994); Herbert et al. (1996); Christopher and Holtum (1998)
C. cryptica	L20784	>100.0	23.0	Leu	.	Met	.	.	Pro	Thr	Met	.	Roessler (1990)
T. gondii cpa	AF157612	5.0	>400.0	Leu	.	Met	.	.	Pro	Thr	Met	.	Jelenska et al. (2002)
T. gondii cya	AF330145	>400.0	>400.0	Leu	.	Met	.	.	.	Arg	Met	.	Jelenska et al. (2002)
Yeast	Z71631	>500.0	>500.0	Leu	.	Met	Val	.	Pro	Thr	Met	Ala	Joachimiak et al. (1997)
Rat (β isoform)	AB004329	NAc	18.0–>100.0	Leu	.	Met	Met	.	.	Ser	Met	.	Seng et al. (2003)

^acp, Plastidic; cy, cytosolic ACCase isoform.

^bDots, Residues identical to those in black-grass chloroplastic ACCase

^cNA, None available.

^dSequence from alfalfa (see text).