Fig 3.

Neutralization breadth and potency against Omicron sub-lineages. (A) Neutralization breadth and potency of BTI mAbs against Wuhan-1, Delta, Beta, BA.1, BA.2, and BA.4 from VAIN1, VAIN2, and VAIN3. Data for each mAb are linked. Red triangle and linking line show the geometric mean IC₅₀ against each variant. Dotted line represents the highest concentration of antibody tested. (B) Comparison of neutralization breadth and potency of BTI mAbs with mAbs isolated from convalescent donors (infection) (5) and an AZD1222 vaccinated donor (6) against Omicron sub-lineages (BA.1, BA.2, and BA.4). Horizontal line represents the geometric mean IC₅₀ against each mAb origin. D’Agostino and Pearson tests were performed to determine normality. Based on the result, a Kruskal-Wallis test with Dunn’s multiple comparison post hoc test was performed. *P < 0.0332, **P < 0.0021, ***P < 0.0002, and ****P < 0.0001 (related to Table S3).