Fig 5.

NTD mAb characterization. (A) Neutralization breadth and potency of NTD-specific mAbs within the different NTD competition groups. Data for each mAb are linked. Dotted line represents the highest concentration of antibody tested. (B) Comparison between neutralization activity (IC₅₀) and binding to Spike or NTD (EC₅₀) by ELISA for NTD-specific mAbs. IC₅₀ and EC₅₀ (half-maximal effective concentrations of binding) values are shown as a heat map for each NTD-specific mAb with the level of binding shown in the key. A cross indicates that the Spike or NTD antigen for that variant was not available to test (related to Fig. S5).