TABLE 2.

Trikafta treatment alters metabolic activity in select kinase null mutants ^b

AFUB no.	Putative function	% change from vehicle	% change from WT
AFUB_012420	Mitogen-activated protein kinase	176.5	139.9
AFUB_053520	Calcium/calmodulin-dependent protein kinase, putative	156.6	118.6
AFUB_017750	Protein kinase, putative	154.8	117.3
AFUB_099170	Protein kinase Yak1, putative	129.1	112.3
AFUB_018600	Protein kinase, putative	105.4	79.9
AFUB_101530	Sensor histidine kinase/response regulator, putative	91.6	79.7
AFUB_098230	Inositol kinase kinase (UvsB), putative	91.0	79.1
AFUB_043130	MAP kinase kinase Ste7	99.4	78.8
AFUB_067080	Putative uncharacterized protein	90.1	78.4
AFUB_055480	Serine/threonine protein kinase, putative	88.2	76.7
AFUB_061120	Protein kinase domain-containing protein	87.9	76.5
AFUB_045550	Calcium/calmodulin-dependent protein kinase, putative	86.6	75.4
AFUB_020650	Two-component osmosensing histidine kinase (Bos1)	85.8	74.7
AFUB_032300	Protein kinase, putative	93.2	73.9
AFUB_071990	N/A a	84.6	73.6
AFUB_063830	Ubiquinone biosynthesis protein, putative	84.0	73.0
AFUB_096660	Putative uncharacterized protein	76.7	66.7
AFUB_040390	Protein kinase domain-containing protein	72.6	63.2

^a N/A, not available.

^b The values in bold were selected for a secondary biomass screen.