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Assessment of tepotinib affinity to MET in cell lysates by fluorescence cross correlation spectroscopy
| MET protein variants | Tepotinib |
|---|---|
| Ki (nM) | |
| MET (1028–1390)-EGFP | 1.3 ± 0.1 |
| MET (1028–1390) [Y1235D]-EGFP | 49 ± 4.9 |
| MET (1028–1390) [Y1234 E/Y1235 E]-EGFP | 66 |
| MET (full-length)-EGFP | 7.6 ± 1.9 |
| MET (full-length) [Y1235D]-EGFP | 75.6 ± 8.1 |
