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Deletion of gut Ffar4 led to a decrease in the abundance of Akkermansia muciniphila. QMD was used to show the most significant dominant microbial species in the two groups of mice (a and b) at different ZTs (c and d) (WT/KO mice, n = 8 per ZT; Villin-Cre/Gko mice, n = 6 per ZT). KO, knockout; WT, wild type. * represents P < 0.05；** represents P < 0.01；*** represents P < 0.001；**** represents P < 0.0001.
