FIG 6.

Pasteurized A. muciniphila can improve transcripts of key genes in glucose metabolism at ZT12 in gut-specific Ffar4 knockout (Gko) mice. Glucose metabolism transcript changes in liver (Glut2, Pkm, and Hk2) and muscle (Glut1, Glut2, Pkm, Gyg, and Gsk3a) are shown in panels a–h. Data are expressed as the mean ± standard error of the mean. Interaction effects analysis was used to analyze differences between groups (P < 0.05 was considered statistically significant using one-way ANOVA). * represents P < 0.05；** represents P < 0.01；*** represents P < 0.001；**** represents P < 0.0001; NS, not significant.