Table 2.
Detailed clinical characteristics of SAPHO patients with a positive family history.
| Patienta | Kinship | Gender | Onset age | Cutaneous manifestation | Bone disease locations | Complication of autoimmune diseases |
|---|---|---|---|---|---|---|
| A-II-4 | Proband | Female | 46 | PPP | ACW + Spine | NA |
| A-I-2 | Mother | Female | 69 | PPP | ACW | NA |
| B-II-5 | Proband | Female | 30 | PPP | ACW + Spine + Mandible | NA |
| B-III-4 | Daughter | Female | 10 | PPP | ACW | NA |
| C–I-2 | Proband | Female | 57 | PPP | ACW + Spine | NA |
| C-II-2 | Daughter | Female | 35 | PPP | ACW | NA |
| D-II-3 | Proband | Female | 63 | PPP | ACW + Spine | NA |
| D-III-2 | Daughter | Female | 35 | PPP | ACW + Spine | NA |
| E-II-6 | Proband | Female | 54 | NA | ACW + Periphral bone | Vitiligo |
| E-II-4 | Sister | Female | 55 | NA | Spine | NA |
| F-II-6 | Proband | Female | 56 | PPP | ACW | NA |
| F-II-7 | Sister | Female | 50 | PPP | ACW + Spine + Periphral bone | NA |
ACW: anterior chest wall; PPP: Palmoplantar pustulosis; NA: Not acquired.
a
Number of patients referred to in the pedigree shown in Fig. 2.