Table 2.
Integrated information of SNPs used for the two-sample Mendelian randomization analysis
| AD (ieu-b-2) |
AD (FinnGen) |
DLB (ebi-a-GCST90001390) |
VaD (FinnGen) |
FTD (ieu-b-43) |
FTD (meta) |
FTD (FinnGen) |
Any dementia (FinnGen) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| nSNP | F | nSNP | F | nSNP | F | nSNP | F | nSNP | F | nSNP | F | nSNP | F | nSNP | F | |
| CPAmax | 6 | 135.529 | 6 | 133.772 | 3 | 62.505 | 6 | 133.772 | 6 | 133.772 | – | – | – | – | 6 | 133.772 |
| CPSmax | 10 | 221.629 | 9 | 199.484 | 9 | 198.063 | 9 | 199.484 | – | – | 6 | 128.390 | 9 | 199.484 | 9 | 199.484 |
| baPWV | 13 | 276.912 | 20 | 430.389 | 15 | 318.223 | 20 | 430.389 | – | – | 5 | 101.569 | 20 | 430.389 | 20 | 430.389 |
| bfPWV | 22 | 462.772 | 24 | 502.480 | 21 | 437.013 | 24 | 502.480 | 2 | 41.712 | 14 | 288.321 | 24 | 502.480 | 24 | 502.480 |
| PAD | 21 | 466.411 | 28 | 620.504 | 32 | 689.841 | 25 | 560.756 | 4 | 79.885 | 17 | 381.185 | 28 | 620.504 | 32 | 747.728 |
| PAD_FinnGen | 32 | 764.484 | – | – | 31 | 792.026 | – | – | 2 | 44.953 | 20 | 487.140 | – | – | – | – |
| pwASI | 27 | 604.263 | 31 | 749.774 | 35 | 811.501 | 34 | 818.562 | 3 | 68.256 | 23 | 512.824 | 36 | 863.547 | 30 | 668.411 |
| CoAS_FinnGen | 46 | 2600.420 | – | – | 44 | 2356.869 | – | – | 5 | 316.476 | 33 | 1743.254 | – | – | – | – |
| CeAS_FinnGen | 9 | 185.995 | – | – | 8 | 162.629 | – | – | 1 | 21.147 | 3 | 60.989 | – | – | – | – |
| ATHSCLE_FinnGen | 9 | 386.684 | – | – | 12 | 589.810 | – | – | 4 | 90.708 | 8 | 361.674 | – | – | – | – |
| CAD | 51 | 4023.882 | 58 | 4335.247 | – | – | 61 | 4514.494 | 8 | 558.928 | 60 | 4169.708 | 61 | 4514.494 | 56 | 4230.495 |
SNP, single nucleotide polymorphism; CPAmax, area of the largest carotid plaque detected; CPSmax, maximal degree of stenosis; PWV: pulse wave velocity; baPWV, brachial-ankle PWV; bfPWV, brachial-femoral PWV; PAD, peripheral artery disease; pwASI, pulse wave arterial stiffness index; CoAS, coronary atherosclerosis; CeAS, cerebral atherosclerosis; ATHSCLE, Atherosclerosis, excluding cerebral, coronary and PAD; CAD, coronary artery disease; AD, Alzheimer’s disease; DLB, dementia with Lewy bodies; FTD, frontotemporal dementia; VaD, vascular dementia; GWAS, genome-wide association study.