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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Epilepsia. 2023 May 18;64(Suppl 3):S49–S61. doi: 10.1111/epi.17640

Table 1. Typical stimulation settings for VNS, DBS, and RNS.

Adapted from: Simpson et al, Epilepsia, 2022. https://pubmed.ncbi.nlm.nih.gov/35700144/

Current, voltage, or charge density Pulse width Frequency Duty cycle %, ON/OFF (min)
Initial Increment Target Initial Target
VNS Normal mode 0.125 – 0.25 mA 0.125 – 0.25 mA 1.5–2 mA 250 μs 20–30 Hz 10%, 0.5 ON / 5 OFF 16–58%
Autostim 0.25 – 0.375 mA 0.125 – 0.25 mA 1.5–2 mA 250 μs 20–30 Hz ON 1 ON 1
Magnet mode 0.5 mA 0.25 mA 2 mA 500 μs 20–30 Hz ON 1 ON 1
DBS (ANT) SANTE protocol 2–3 mA/V per cathode 1–2 mA/V 5–6 mA/V 90 μs 145 Hz 17%, 1 ON / 5 OFF
RNS Initial 0.5 μC/cm2 0.5 μC/cm2 2–6 μC/cm2 160 μs 200 Hz