Table 3.
Plasma pharmacokinetics (PK) parameters of triamcinolone acetonide (TCA) (PKAS)
| Parameter | Statistic | Treatment sequence | |
|---|---|---|---|
| TCA + LOR (N = 20) | LOR + TCA (N = 20) | ||
| Tmax (h) | Median | 8.00 | 8.00 |
| Range | 1.00–336.00 | 1.00–48.00 | |
| Tlast (h) | Median | 336 | 336 |
| Range | 176–336 | 168–336 | |
| Cmax (pg/mL) | Geo mean (Geo CV%) | 6250 (318.3) | 3510 (333.7) |
| Range | 374–44,300 | 454–40,200 | |
| AUC0–168 (pg × h/mL) | Geo mean (Geo CV%) | 266,000 (155.6) | 201,000 (154.3) |
| Range | 48,100–1,290,000 | 49,200–1,280,000 | |
| AUC0–last (pg × h/mL) | Geo mean (Geo CV%) | 353,000 (108.0) | 281,000 (107.7) |
| Range | 104,000–1,300,000 | 89,500–1,330,000 | |
| AUC0–inf (pg × h/mL) | n | 7 | 5 |
| Geo mean (Geo CV%) | 915,000 (46.0) | 960,000 (28.4) | |
| AUCextrap (%) | n | 7 | 5 |
| Geo mean (Geo CV%) | 0.51 (780.2) | 0.19 (68.1) | |
| t1/2 (h) | n | 7 | 7 |
| Geo mean (Geo CV%) | 48.54 (122.3) | 53.99 (157.7) | |
LOR lorecivivint