Table 4.
Hazard ratios of cumulative radioactive iodine dose for all cancer combined and specific cancer types
| Adjusted HR according to dose level (95% CI) | Adjusted HR according to dose level (95% CI) | Adjusted HR according to dose level (95% CI) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total* | Male** | Female** | ||||||||||
| Type of SPM | 3.7 GBq or less | 3.71–7.40 GBq | 7.41–11.10 GBq | > 11.10 GBq | 3.7 GBq or less | 3.71–7.40 GBq | 7.41–11.10 GBq | > 11.10 GBq | 3.7 GBq or less | 3.71–7.40 GBq | 7.41–11.10 GBq | > 11.10 GBq |
| Any SPM |
1.013 (0.979–1.049) |
1.214 (1.167–1.264) |
1.422 (1.258–1.607) |
1.693 (1.545–1.854) |
0.962 (0.885–1.046) |
1.172 (1.072–1.281) |
1.083 (0.836–1.403) |
1.769 (1.505–2.079) |
1.028 (0.99–1.068) |
1.231 (1.177–1.287) |
1.553 (1.351–1.785) |
1.651 (1.478–1.844) |
| All solid cancer |
1.017 (0.982–1.054) |
1.212 (1.163–1.263) |
1.402 (1.234–1.592) |
1.696 (1.544–1.863) |
0.98 (0.899–1.068) |
1.195 (1.089–1.31) |
1.086 (0.828–1.423) |
1.809 (1.531–2.138) |
1.03 (0.99–1.071) |
1.223 (1.168–1.28) |
1.52 (1.316–1.756) |
1.642 (1.465–1.84) |
| Lip, oral cavity, and pharynx (C00-C14) |
0.906 (0.811–1.012) |
1.404 (1.251–1.576) |
1.812 (1.294–2.536) |
1.792 (1.363–2.355) |
0.672 (0.472–0.957) |
1.219 (0.886–1.677) |
1.213 (0.497–2.959) |
2.131 (1.252–3.627) |
0.94 (0.837–1.056) |
1.435 (1.268–1.625) |
1.952 (1.358–2.807) |
1.667 (1.21–2.295) |
| Esophagus (C15) |
0.618 (0.351–1.087) |
0.82 (0.441–1.524) |
0.805 (0.111–5.816) |
1.872 (0.679–5.163) |
0.468 (0.209–1.048) |
0.9 (0.435–1.862) |
0.588 (0.081–4.282) |
0.868 (0.388–1.941) |
0.635 (0.191–2.117) |
3.419 (0.461–25.336) |
6.054 (1.815–20.191) |
|
| Stomach (C16) |
1.062 (0.943–1.196) |
1.249 (1.09–1.432) |
0.859 (0.507–1.457) |
2.047 (1.551–2.702) |
1 (0.796–1.256) |
1.232 (0.967–1.569) |
0.572 (0.213–1.536) |
1.807 (1.158–2.819) |
1.092 (0.95–1.255) |
1.263 (1.07–1.49) |
1.066 (0.571–1.991) |
2.223 (1.559–3.17) |
| Colon and rectum (C18-C21) |
1.014 (0.916–1.123) |
1.26 (1.122–1.416) |
1.337 (0.919–1.945) |
1.406 (1.05–1.882) |
0.928 (0.723–1.192) |
1.093 (0.835–1.431) |
0.971 (0.431–2.184) |
1.145 (0.641–2.047) |
1.035 (0.925–1.157) |
1.306 (1.149–1.486) |
1.474 (0.966–2.248) |
1.508 (1.077–2.113) |
| Liver (C22) |
0.945 (0.794–1.124) |
1.054 (0.859–1.294) |
0.969 (0.482–1.951) |
1.803 (1.195–2.72) |
1.037 (0.751–1.433) |
1.173 (0.824–1.669) |
0.884 (0.281–2.778) |
2.281 (1.288–4.039) |
0.913 (0.743–1.122) |
1.008 (0.784–1.296) |
1.046 (0.432–2.53) |
1.481 (0.812–2.701) |
| Gallbladder and biliary tract (C23-24) |
0.981 (0.728–1.322) |
1.377 (0.99–1.915) |
1.276 (0.407–4.005) |
1.258 (0.515–3.069) |
0.947 (0.459–1.958) |
1.527 (0.757–3.081) |
2.359 (0.715–7.782) |
0.987 (0.711–1.37) |
1.339 (0.92–1.947) |
1.851 (0.589–5.817) |
0.742 (0.184–3.001) |
|
| Pancreas (C25) |
1.076 (0.856–1.353) |
0.997 (0.742–1.34) |
1.031 (0.384–2.771) |
1.421 (0.73–2.766) |
0.896 (0.515–1.559) |
1.221 (0.693–2.152) |
1.804 (0.65–5.004) |
1.121 (0.871–1.442) |
0.926 (0.654–1.311) |
1.544 (0.574–4.158) |
1.205 (0.496–2.927) |
|
| Larynx (C32) |
0.632 (0.336–1.19) |
0.674 (0.318–1.425) |
2.896 (0.9–9.318) |
2.757 (1.094–6.949) |
0.538 (0.238–1.216) |
0.67 (0.281–1.601) |
2.309 (0.554–9.624) |
2.643 (0.936–7.466) |
0.834 (0.303–2.296) |
0.66 (0.151–2.888) |
5.421 (0.716–41.039) |
3.079 (0.406–23.337) |
| Lung(C33-C34) |
1.118 (1.002–1.247) |
1.42 (1.255–1.608) |
2.192 (1.578–3.044) |
2.862 (2.276–3.601) |
0.937 (0.737–1.189) |
1.219 (0.95–1.565) |
2.256 (1.339–3.798) |
2.527 (1.72–3.712) |
1.176 (1.039–1.33) |
1.493 (1.295–1.722) |
2.094 (1.371–3.199) |
3.009 (2.26–4.005) |
| Bone and soft tissue (C40-C41) |
1.296 (0.775–2.166) |
1.267 (0.681–2.358) |
3.751 (1.161–12.12) |
12.226 (6.759–22.117) |
0.821 (0.265–2.545) |
0.811 (0.229–2.878) |
2.741 (0.356–21.115) |
1.73 (0.225–13.322) |
1.48 (0.828–2.645) |
1.446 (0.709–2.95) |
4.065 (0.972–17.01) |
18.855 (10.013–35.506) |
| Skin (C43-C44) |
0.939 (0.742–1.187) |
1.041 (0.784–1.382) |
1.725 (0.814–3.659) |
1.048 (0.494–2.223) |
1.128 (0.674–1.886) |
0.923 (0.489–1.741) |
0.785 (0.108–5.688) |
0.463 (0.064–3.354) |
0.896 (0.688–1.167) |
1.075 (0.783–1.475) |
2.156 (0.957–4.856) |
1.325 (0.589–2.985) |
| Breast (C50) |
0.989 (0.921–1.062) |
1.015 (0.93–1.108) |
1.215 (0.921–1.603) |
0.916 (0.701–1.196) |
0.841 (0.087–8.087) |
0.989 (0.921–1.063) |
1.016 (0.931–1.109) |
1.217 (0.922–1.605) |
0.918 (0.703–1.199) |
|||
| Cervix (C53) |
0.96 (0.753–1.224) |
1.237 (0.942–1.626) |
0.539 (0.134–2.17) |
1.115 (0.496–2.507) |
0.96 (0.753–1.224) |
1.237 (0.942–1.626) |
0.54 (0.134–2.17) |
1.115 (0.496–2.507) |
||||
| Uterus (C54-C55) |
1.367 (1.097–1.703) |
1.201 (0.905–1.594) |
0.581 (0.144–2.338) |
2.031 (1.078–3.828) |
1.367 (1.097–1.703) |
1.201 (0.905–1.594) |
0.581 (0.144–2.338) |
2.031 (1.078–3.828) |
||||
| Ovary (C56) |
1.209 (0.959–1.524) |
1.28 (0.967–1.694) |
0.898 (0.287–2.808) |
1.44 (0.678–3.056) |
1.209 (0.959–1.524) |
1.28 (0.967–1.694) |
0.899 (0.288–2.808) |
1.44 (0.678–3.057) |
||||
| Prostate (C61) |
1.232 (1.007–1.507) |
1.298 (1.032–1.632) |
0.931 (0.44–1.97) |
1.462 (0.919–2.326) |
1.232 (1.007–1.507) |
1.298 (1.032–1.632) |
0.931 (0.44–1.97) |
1.462 (0.919–2.326) |
||||
| Testis (C62) |
0.408 (0.049–3.391) |
0.546 (0.066–4.545) |
0.408 (0.049–3.391) |
0.546 (0.066–4.545) |
||||||||
| Kidney (C64) |
1.118 (0.923–1.353) |
1.453 (1.179–1.79) |
2.013 (1.156–3.505) |
0.986 (0.526–1.852) |
1.106 (0.801–1.529) |
1.424 (1.021–1.987) |
1.194 (0.441–3.234) |
1.661 (0.843–3.272) |
1.124 (0.887–1.423) |
1.473 (1.128–1.925) |
2.888 (1.482–5.628) |
0.212 (0.03–1.512) |
| Bladder (C67) |
1.43 (1.085–1.885) |
0.968 (0.662–1.416) |
1.032 (0.329–3.242) |
1.648 (0.807–3.366) |
1.502 (1.039–2.172) |
0.869 (0.52–1.454) |
0.488 (0.068–3.506) |
1.716 (0.747–3.94) |
1.351 (0.89–2.051) |
1.126 (0.641–1.977) |
2.322 (0.568–9.495) |
1.453 (0.355–5.941) |
| Brain and CNS (C70-72) |
0.908 (0.657–1.255) |
1.847 (1.361–2.507) |
1.693 (0.626–4.58) |
4.065 (2.381–6.941) |
0.598 (0.245–1.458) |
2.188 (1.167–4.104) |
2.761 (0.653–11.665) |
3.376 (1.174–9.709) |
0.977 (0.689–1.384) |
1.744 (1.227–2.479) |
1.218 (0.301–4.931) |
4.38 (2.357–8.139) |
| Other and ill-defined |
0.885 (0.744–1.053) |
1.157 (0.954–1.403) |
1.757 (1.05–2.939) |
1.81 (1.2–2.729) |
0.754 (0.51–1.112) |
0.975 (0.654–1.454) |
0.958 (0.304–3.018) |
1.372 (0.639–2.946) |
0.924 (0.76–1.122) |
1.219 (0.978–1.518) |
2.17 (1.221–3.856) |
2.032 (1.25–3.304) |
| All hematologic cancer |
0.949 (0.818–1.102) |
1.236 (1.048–1.458) |
1.717 (1.087–2.712) |
1.602 (1.097–2.341) |
0.781 (0.572–1.067) |
0.928 (0.665–1.294) |
1.059 (0.435–2.579) |
1.272 (0.672–2.409) |
1.01 (0.853–1.197) |
1.368 (1.131–1.655) |
2.121 (1.246–3.61) |
1.785 (1.114–2.859) |
| Non-Hodgkin's lymphoma (C82-C86, C88, C96) |
0.636 (0.51–0.793) |
0.766 (0.593–0.988) |
0.576 (0.215–1.544) |
1.274 (0.746–2.173) |
0.471 (0.295–0.751) |
0.405 (0.228–0.719) |
0.937 (0.298–2.952) |
0.746 (0.275–2.022) |
0.701 (0.546–0.902) |
0.945 (0.711–1.257) |
0.253 (0.036–1.805) |
1.663 (0.884–3.126) |
| Hodgkin's Disease (C81) |
0.894 (0.352–2.268) |
0.237 (0.031–1.782) |
1.86 (0.246–14.063) |
1.001 (0.194–5.159) |
0.86 (0.277–2.668) |
0.362 (0.047–2.783) |
3.262 (0.423–25.136) |
|||||
| Multiple myeloma (C90) |
1.101 (0.751–1.612) |
1.104 (0.685–1.78) |
1.273 (0.596–2.72) |
1.902 (0.89–4.066) |
1.049 (0.674–1.632) |
0.812 (0.429–1.537) |
||||||
| Leukemia (C91-C95) |
1.741 (1.343–2.257) |
2.759 (2.116–3.599) |
6.202 (3.635–10.581) |
3.505 (1.982–6.198) |
1.578 (0.888–2.804) |
2.42 (1.384–4.231) |
2.328 (0.556–9.749) |
4.306 (1.791–10.351) |
1.789 (1.337–2.392) |
2.869 (2.122–3.88) |
8.137 (4.574–14.474) |
2.941 (1.369–6.317) |
SPM, Second primary malignancy;
Reference: non-treatment (No RAI)
*Adjusted for age and sex
**Adjusted for age