Table 1.
Demographic characteristics of IL-6Ri vs. JAKi initiators
| Covariates | IL-6Ri initiators N = 100 |
JAKi initiators N = 129 |
Standardized differencea |
|---|---|---|---|
| Age (years), mean (SD), N | 57.2 (11.3), 100 | 59.2 (12.7), 128 | 0.167 |
| RA duration (years), mean (SD), N | 15.4 (10.3), 99 | 15.6 (10.5), 129 | 0.020 |
| Female, n (%), N | 81 (81), 100 | 108 (84), 128 | 0.089 |
| White, n (%), N | 90 (90), 100 | 97 (75), 129 | 0.398 |
| Private insurance, n (%), N | 75 (75), 100 | 90 (70), 129 | 0.117 |
| Working status, n (%) | N = 96 | N = 127 | 0.301 |
| Full time | 30 (31) | 46 (36) | |
| Part time | 8 (8) | 5 (4) | |
| Retired | 20 (21) | 37 (29) | |
| Other | 38 (40) | 39 (31) | |
| Smoking status, n (%) | N = 100 | N = 129 | 0.232 |
| Never | 47 (47) | 65 (50) | |
| Previous | 25 (25) | 40 (31) | |
| Current | 28 (28) | 24 (19) | |
| Alcohol use: yes, n (%), N | 36 (38), 94 | 53 (43), 123 | 0.098 |
| BMI (kg/m2), mean (SD), N | 30.8 (7.7), 100 | 30.0 (7.1), 129 | 0.103 |
| Seropositivity, n (%) | N = 94 | N = 121 | 0.064 |
| CCP+ and/or RF+ | 53 (56) | 72 (60) | |
| CCP− and RF−b | 9 (10) | 11 (9) | |
| CCP and RF missing | 32 (34) | 38 (31) | |
| History of comorbidities, n (%) | N = 100 | N = 129 | |
| CVDc | 18 (18) | 15 (12) | 0.180 |
| Malignancyd | < 5 | 7 (5) | 0.253 |
| Serious infectione | 10 (10) | 13 (10) | 0.003 |
BMI body mass index, CCP anti-cyclic citrullinated peptide, CVD cardiovascular disease, IL-6Ri interleukin-6 receptor inhibitor, JAKi Janus kinase inhibitor, n/N number of patients, RA rheumatoid arthritis, RF rheumatoid factor, SD standard deviation
aPresented as absolute values
bIf a patient was CCP− and RF information was missing, or vice versa, they were included in this group
cHistory of CVD includes myocardial infarction, stroke, acute coronary syndrome, coronary artery disease, congestive heart failure, revascularization procedure including percutaneous coronary intervention, coronary artery bypass grafting or coronary artery stents, ventricular arrhythmia, cardiac arrest, unstable angina, peripheral arterial disease, other CVDs, pulmonary embolism, carotid artery disease, deep vein thrombosis, and transient ischemic attack
dHistory of malignancy includes lymphoma, lung cancer, breast cancer, non-melanoma skin cancer, and other cancer
eSerious infections include infections that led to hospitalization or intravenous antibiotics: joint/bursa, cellulitis, sinusitis, diverticulitis, sepsis, pneumonia, bronchitis, gastroenteritis, meningitis, urinary tract infection, upper respiratory tract infection, or infection of other specified sites