Table 1.

Operational definitions of the 4 PPFs

Poor prognosis factor	Criteria for post hoc analyses [7, 8, 16, 21, 22]
Seropositivity for RF and/or anti-CCP	Seropositivity for RF or anti-CCP antibodies
High disease activity	DAS28(CRP) > 5.1
High baseline levels of acute reactants	hsCRP ≥ 4 mg/L or ≥ 6 mg/L, depending on analysis
Radiographic bone erosion at disease onset	≥ 1 joint erosion on hand/wrist or foot radiographs (erosion score > 0 at baseline)a

CCP cyclic citrullinated peptide, CRP C-reactive protein, DAS28 Disease Activity Score in 28 joints, hsCRP high-sensitivity CRP, PPF poor prognostic factor, RF rheumatoid factor

^aOr ≥ 3 erosions if seronegative for anti-CCP antibodies or RF in FINCH 1